Current Issues of Pharmacy and Medical Sciences

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Curr Issues Pharm Med Sci., Vol. 32, No. 4, 229-235

Tomasz Blicharski1, Katarzyna Swiader2*, Anna Serefko3
Sylwia Kulczycka-Mamona2, Michal Kolodziejczyk4, Aleksandra Szopa3*

1 Chair and Department of Rehabilitation and Orthopedics, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland
2 Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
3 Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
4 Department of Applied Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland


https://doi.org/10.2478/cipms-2019-0039

Abstract

Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.

Keywords

bilayer tablet, multi-layer tablet, challenges in technology, compression. 

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