Biochemical aspects of KB-28 compound on physically loaded study subjects
Curr Issues Pharm Med Sci., Vol. 32, No. 3, 168-172
Olena Toziuk1*, Olga Krasna2, Olena Kryvoviaz1, Victoria Rodinkova1,
Andrii Melnyk3, Tanya Ivko1, Alona Voronkina1, Viktoriia Hutsol1
1 Pharmacy Department, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, Ukraine
2 General Pharmacy Department, Odessa National Medical University, Valikhovsky Lane 2, Odessa, Ukraine
3 Department of Biological and General Chemistry, National Pirogov Memorial Medical University, Vinnytsya, Pirogov 56, Vinnytsia, Ukraine
In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.
acute lymphoblastic leukemia, physical endurance, carbohydrate metabolism, lipid metabolism, 2-ethylthiobenzimidazole hydrobromide, sodium 2-(tetrazolo[1,5-c]quinazoline-5-ylthio)acetate.