Current Issues of Pharmacy and Medical Sciences

Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

Curr Issues Pharm Med Sci., Vol. 32, No. 3, 125-129

Samuel O. Onoja1*, Gloria Daniel-Igwe2, Emmanuel Ejiofor3,4,
Christiana C. Mbakwe4, Ugochuhwu S. Okeke4, Maxwell I. Ezeja1,
Yusuf N. Omeh4, Isaac U. Asuzu5

Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Nigeria
Department of Veterinary Pathology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Nigeria
3 Department of Biological Sciences, Clifford University, Owerrinta, Abia State, Nigeria
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Nigeria
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, 410001 Enugu State, Nigeria


https://doi.org/10.2478/cipms-2019-0023

Abstract

This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats. The extract of P. pinnata root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C in hot air oven. The extract was administered once daily per os at 50, 100 and 200 mg/kg for 21 consecutive days. Distilled water (5 mL/kg) and glibenclamide (2 mg/kg) were used as the vehicle and reference standard, respectively. The serum lipid profile, markers of liver and kidney functions, antioxidant status (malondialdehyde level, superoxide dismutase and catalase activities), histopathological changes in liver and kidney were examined 24h after the last treatment on day 21. The extract reduced serum lipid profile, markers of liver and kidney functions of treated rats relative to vehicle-treated rats. The superoxide dismutase and catalase activities of the extract treated rats were also elevated relative to the vehicle-treated rats. The extract reversed liver and kidney injuries induced by alloxan in the treated rats. This study provides some basic information which suggest that P. pinnata could be effective in managing diabetic complications.

Keywords

antioxidant, Paullinia pinnata, hepatoprotective, nephroprotective, lipid profile.

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