Current Issues of Pharmacy and Medical Sciences

The effects of pomegranate peel extract on recurrent aphthous stomatitis

Curr Issues Pharm Med Sci., Vol. 32, No. 3, 115-120

Sara Darakhshan1,2 , Mohammad Malmir3, Fereshteh Bagheri2 ,
Mohsen Safaei4 ,Roohollah Sharifi5 , Masoud Sadeghi6 ,
Masoud Hatami7 , Hamid Reza Mozaffari6,7* , Reza Tahvilian2*

1 Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran
2 Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
6 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
7 Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran


https://doi.org/10.2478/cipms-2019-0021

Abstract

As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (Punica granatum), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, doubleblind study was conducted on 56 patients. Herein, 28 patients were advised to apply PPE gel, and the other 28 patients were given placebo gel, twice daily for one week. Efficacy evaluations were made at days 0 (before using the gel), 3, 5 and 7. The mean values of ulcer size, pain and healing duration of ulcers were compared in both groups. PPE gel was significantly effective in reducing the pain (p<0.001), ulcer size (p<0.001), and healing duration of ulcers (p<0.001) over a period of one week. PPE in the form of oral gel can be used in the management of aphthous ulcers.

Keywords

antioxidant, pomegranate peel extract, recurrent aphthous stomatitis.

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