Current Issues of Pharmacy and Medical Sciences

Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats

Curr Issues Pharm Med Sci., Vol. 32, No. 2, 57-62

Nataliya Denysenko, Vitaliy Yemelyanenko, Iryna Fomenko, Alexander Sklyarov*

Department of Biochemistry, Danylo Halytskyy Lviv National Medical University, Pekarska, 69, 79010, Lviv, Ukraine


Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through the activation of various types of 5-HT receptors, in particular, 5-HT4 receptors, since the latter are identified on colon cells membranes (enterocytes, smooth muscles and endothelium). The aim of our study was to determine the effect of 5-НT4 receptors agonist (mosapride) on nitrogen (II) oxide production and lipid peroxidation in CM and colon muscle tissue (CMT) under the conditions of experimental ulcerative colitis (UC).


experimental colitis, mosapride, NO-synthase, lipid peroxidation, antioxidant enzymes.


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