Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite
Curr Issues Pharm Med Sci., Vol. 32, No. 1, 29-33
Mohsen Safaei1*, Mojtaba Taran2, Razieh Rezaei3, Kamran Mansouri3,
Hamid Reza Mozaffari3,4, Mohammad Moslem Imani5, Roohollah Sharifi6
1 Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Nanobiotechnology, Faculty of Science, Razi University, Kermanshah, Iran
3 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
6 Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
Given the increase in global mortality rate due to various types of cancer, the present study aimed to develop optimal conditions for the synthesis of cellulose-magnesium oxide nanocomposite with favorable anticancer activity. For this purpose, the Taguchi method was used to design nine experiments with varied ratios of cellulose biopolymer, magnesium oxide nanoparticles and different stirring times. The scanning electron microscopy (SEM) images confirmed the formation of cellulose-magnesium oxide nanocomposite. The anticancer activity level of nine nanocomposites studied was evaluated using MTT assay on Michigan Cancer Foundation-7 (MCF-7) cell line.
The nanocomposite synthesized in experiment 9 (8 mg/ml of magnesium oxide, 2 mg/ml of cellulose and stirring time of 60 min) showed the highest growth inhibitory activity on the cancer cells. Based on the attained results,e cellulose-magnesium oxide nanocomposite synthesized in optimal conditions can be used as an eligible anticancer agent.
cytotoxicity, magnesium oxide nanoparticles, bacterial cellulose, biopolymer, nanocomposite, Taguchi method.