Increasing efficacy of treatment in patients with steatohepatitis and concomitant chronic colitis
Curr Issues Pharm Med Sci., Vol. 32, No. 1, 23-26
Elina G. Manzhalii1*, Valentyna O. Moyseyenko1, Tetyana M. Falalyeyeva2,
Olena I. Tsyryuk2, Vitaliy E. Kondratiuk1, Taras D. Nykula1
1 Department of Internal Medicine propedeutics No. 2, Bogomolets National Medical University, T. Shevchenko 13, 01601, Kyiv, Ukraine
2 Educational and Scientific Centre «Institute of Biology and Medicine», Taras Shevchenko National University of Kyiv, Vladimirskaya 64, 01601, Kyiv, Ukraine
This paper presents the results of a study of patients with nonalcoholic steatohepatitis, alcoholic steatohepatitis, and drug-induced liver injury with concomitant colitis and the development of biliary insufficiency that manifests as a significant decrease in the volume of bile acids and bile. In patients with liver injury and concomitant colitis, changes in intestinal microflora were marked. After a combination therapy of this pathology with phosphatidylcholine and glycyrrhizic acid, an improvement of biochemical, clinical indicators was observed, as well as a decrease in fatty degeneration and reduction of elastographic indicators of liver fibrosis. The introduction of the drug formulations phosphatidylcholine and glycyrrhizic acid in the complex of conservative treatment of liver injury with concomitant colitis helps to prevent hepatic and intestinal complications and to increase the treatment efficacy of these diseases.
phosphatidylcholine, glycyrrhizic acid, steatohepatitis, drug-induced liver injuries, biliary insufficiency, chronic colitis.