Current Issues of Pharmacy and Medical Sciences

Prevalence and antibiotic susceptibility pattern of extended spectrum beta lactamases producing Escherichia coli isolated from outpatients with Urinary Tract Infections in Babol, Northern of Iran

Curr Issues Pharm Med Sci., Vol. 31, No. 2, 61-64

Mana Baziboroun1, Masomeh Bayani*1, Zahra Poormontaseri2
Mehran Shokri1, Tahmine Biazar1

1 Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2 Department of infectious disease, Fasa University of Medical Science, Fars, Iran

DOI: 10.1515/cipms-2018-0013 10.1515/cipms-2018-0011


The incidence of community-acquired UTIs due to extended-spectrum beta-lactamase (ESBL) producing E.coli isolates, has increased worldwide and is considered a great problem in the treatment of infections. The aim of this study was to determine the prevalence of ESBL producing E.coli isolates in urine samples of outpatients in Babol, North of Iran. A total of 3699 urine samples from outpatients referred to Yahyanejad Hospital, Babol, Iran, were collected during 15 months, from March 2016 to June 2017. The samples were processed for bacterial culture using conventional methods, while antimicrobial susceptibility testing for E.coli isolates was performed by the disc diffusion method. The prevalence of ESBL producing E.coli isolates were assessed by Double-Disc tests. Of 3699 tested sample, 201 samples showed the growth of pathogens and among them, 106 isolates (52/7%) were E.coli. The rate of ESBL producing E.coli isolates was 25/4%.The majority (81/5%) of the isolates were from females. High percent resistance was found against ceftazidime, cefotaxime, ceftriaxone, cefixime and ciprofloxacin, ranging from 61-100%, while the highest percent susceptibility was seen to meropenem, piperacillin-tazobactam (100%), followed by nitrofurantoin and amikacin (91%). The high prevalence of ESBL producing E.coli isolates from outpatients calls for the need to aware of this increasing resistance between uropathogens and update bacterial susceptibility data and to set up our empirical therapy accordingly.

Full text


antibiotic resistance, extended spectrum beta lactamase, Escherichia coli, urinary tract infection.


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