Current Issues of Pharmacy and Medical Sciences

Ultrastructural changes in murine liver following HSV infection and stroke

Curr Issues Pharm Med Sci., Vol. 31, No. 1, 10-12

Natalia Motorna1, Svetlana Rybalko2, Tatyana Kvitnitskaya-Ryzhova3,
Daria Starosyla2, Iryna Strokina1, Rostyslav Kaminsky1,
Sergey Savosko1, Liudmyla Sokurenko1, Yuri Chaikovsky1

O.O. Bogomolets National Medical University, Department of Histology and Embryology, T. Shevchenko Blvd 13, 01601 Kyiv, Ukraine
2 Gromashevsky L.V. Institute of Epidemiology and Infection Diseases of NAMS of Ukraine, Kyiv, Ukraine
3 State Institution “D.F. Chebotarev Institute of Gerontology” of NAMS of Ukraine, Kyiv, Ukraine

DOI: 10.1515/cipms-2018-0002

Abstract

The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease.

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Keywords

liver, ultrastructure, herpes simplex virus type I, stroke.

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