Current Issues of Pharmacy and Medical Sciences

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Curr Issues Pharm Med Sci., Vol. 30, No. 3, 119-122

Adrian Jarzynski, Anastazja Boguszewska, Ewa Kliszczewska, 
Lukasz Rolniak, Anna Dworzanska, Malgorzata Polz-Dacewicz 

Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland

DOI: https://doi.org/10.1515/cipms-2017-0021

Abstract

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV – associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.

Full Text 


Keywords

TP53, methylation, OSCC, EBV, HPV.

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