Current Issues of Pharmacy and Medical Sciences

Leptin and interleukin-6 level in patients with hypertension and obesity combined with non-alcoholic steatohepatitis during treatment with sartans and statins

Curr Issues Pharm Med Sci., Vol. 30, No. 2, 57-60

Olesya Bochar1, Eugene Sklyarov1, Volodymyr Bochar2

1 Postgraduate Department №1 Therapy and Medical Diagnostics Danylo Halytsky Lviv National Medical University, Ukraine
2 Postgraduate Department of surgery and endoscopy Danylo Halytsky Lviv National Medical University, Ukraine

DOI: https://doi.org/10.1515/cipms-2017-0011

Abstract

The results of treatment of patients with arterial hypertension and obesity combined with non-alcoholic steatohepatitis are presented in article. Herein, the combined use of olmesartan or telmisartan with atorvastatin for 12 weeks had a positive impact on the physical condition of patients with arterial hypertension and obesity. This effect was manifested by maintenance of optimal blood pressure, the reduction of subjective complaints and the improvement of heart hemodynamics. Administration of sartans and statins to patients with arterial hypertension combined with obesity and non-alcoholic steatohepatitis led to a significant reduction of LDL (p<0.01) and LDL cholesterol levels (p<0.01), as well as the values of leptin (p<0.01) and IL-6 (p<0.01). The combination of olmesartan or telmisartan with atorvastatin not only allows a control of BP, but also a reduction of the pro-atherogenic fractions of blood lipids, hyperleptinaemia and levels of pro-inflammatory IL-6, hence, in this manner, improving the patient general condition.

Keywords

arterial hypertension, obesity, non-alcoholic steatohepatitis, olmesartan, telmisartan, atorvastatin.

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