Current Issues of Pharmacy and Medical Sciences

The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations

Curr Issues Pharm Med Sci., Vol. 30, No. 1, 43-49

Aneta Berner-Strzelczyk1, Agnieszka Jach1, Justyna Kolodziejska1,
Michal Kołodziejczyk1, Malgorzata Godlewska1, Magdalena Piechota-Urbanska2

1 Department of Drug Form Technology, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
2 Department of Applied Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland

DOI: https://doi.org/10.1515/cipms-2017-0010

Abstract

In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern excipients. This translates into increased interest in the topical use of NSAIDs. The aim of this study was to create series of effective oil in water (O/W) diclofenac sodium cream formulations that differ in the applied fatty phase, utilizing Gelot TM64 (Gattefossé) (a modern non-ionic emulsifier). In the produced prescriptions, estimation was made of the effect of this on the rheological parameters and the pharmaceutical availability of the diclofenac sodium. Herein, the hydrophilic petrolatum-based cream demonstrated the highest rate of release of the active agent, as well as the best set of beneficial rheological parameters.

Keywords

diclofenac sodium, emulsifiers, rheology, pharmaceutical availability.

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