Current Issues of Pharmacy and Medical Sciences

Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Curr Issues Pharm Med Sci., Vol. 29, No. 1, 14-21

Magdalena Polakowska1, Jolanta Orzelska-Górka2, Sylwia Talarek2

Student Research Group at the Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4A, 20-093 Lublin, Poland
Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4A, 20-093 Lublin, Poland

DOI:  10.1515/cipms-2016-0004

 

Abstract

Nitric oxide (NO) is a relatively novel messenger that plays a significant role in a wide range of physiological processes. Currently, it is known that, both, lack and excess of NO can cause diseases, thus a lot of substances have been discovered and utilized which can change the concentration of this molecule within the organism. The aim of the present work is to provide an overview of currently used agents modulating the L-arginine:NO:cGMP pathway, as well as to summarize current understanding of their pharmacological profiles. Nowadays, most of these agents are employed particularly in the treatment of cardiovascular diseases. Further studies can hold promise for enhancing the therapeutic equipment for a variety of other impairments, such as osteoporosis, and also in treatments of the central nervous system.

 

FULL TEXT

Keywords

nitric oxide, vasodilators, nebivolol, sildenafil, statins, L-arginine.

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