Current Issues of Pharmacy and Medical Sciences

Littoral cell angioma mimicking metastatic tumors

Curr Issues Pharm Med Sci., Vol. 28, No. 4, Pages 247-249

Justyna Szumilo1, Anna Ostrowska1*, Malgorzata Zdunek1, Slawomir Rudzki2,
Tomasz Chroscicki3, Elzbieta Czekajska-Chehab4, Franciszek Burdan3

1 Chair and Department of Clinical Pathology, Medical University of Lublin, 8b Jaczewskiego, 20-090 Lublin, Poland
2 Chair and Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, 8 Jaczewskiego, 20-954 Lublin, Poland
3 Chair and Department of Human Anatomy, Medical University of Lublin, 4 Jaczewskiego, 20-090 Lublin, Poland
4 1st Department of Radiology, Medical University of Lublin, 8 Jaczewskiego, 20-954 Lublin, Poland

DOI: 10.1515/cipms-2015-0081


Littoral cell angioma is a rare primary, vascular tumor thought to originate from the endothelial cells lining the sinuses of the splenic red pulp (the “littoral cells”). It is a benign, usually asymptomatic lesion diagnosed incidentally. Ultrasound and tomography appearance is not characteristic and histopathological examination is required. This work provides a case-study of littoral cell angioma which was seen in a 55-year-old female who complained of non-specific upper abdominal pain. Computed tomography revealed multiple hypo-attenuated splenic lesions suggestive for metastasis. A splenectomy was performed and routine microscopic examination supported by immunohistochemistry reactions with CD68, CD34 and CD31 showed littoral cell angioma. 

Full text


littoral cell angioma, spleen, splenic tumor, splenic metastasis.


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