Current Issues of Pharmacy and Medical Sciences

Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model ...

Curr Issues Pharm Med Sci., Vol. 28, No. 3, Pages 204-207

Aleksandra Wlaz, Maria W. Kondrat-Wrobel, Katarzyna Zaluska,
Ewelina Kochman, Anna R. Rekas, Jarogniew J. Luszczki

1 Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland
2 Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland


DOI: 10.1515/cipms-2015-0073

Abstract

This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

Full text

Keywords

6 Hz psychomotor seizure model, antiepileptic drugs, drug interactions, gabapentin, levetiracetam, isobolographic analysis.

Calendar

December 2019

Mon Tue Wed Thu Fri Sat Sun
            01
02 03 04 05 06 07 08
09 10 11 12 13 14 15
16 17 18 19 20 21 22
23 24 25 26 27 28 29
30 31