Current Issues of Pharmacy and Medical Sciences

Xanthogranulomatous urethritis and cystitis: a rare clinical and pathological entity

Curr Issues Pharm Med Sci., Vol. 28, No. 3, Pages 149-150

Dorota Lewkowicz1*, Lech Wronecki1, Iwona Pasnik1, Waldemar Bialek2,
Beata Walczyna1, Agnieszka Fronczek1

1 Department of Clinical Pathology, Medical University of Lublin, Jaczewski 8, 20-090 Lublin, Poland
2 Department of Urology, 1st Military Hospital, Racławickie 23, 20-904 Lublin, Poland

DOI: 10.1515/cipms-2015-0061


Xanthogranulomatous inflammation of the urethra and the urinary bladder is a very rare pathological condition characterized by a chronic inflammatory infiltration composed mainly of foamy macrophages, with the presence of multinucleated giant cells. In a clinical examination, it can mimic urinary bladder carcinoma. This report presents the extremely rare case of a co-existing xanthogranulomatous urethritis and cystitis in a 64-year-old woman with recurrent dysuria, and with the suspicion of malignancy – as indicated on the basis of a cystoscopic examination. The standard treatment of this disorder is surgical resection, but in the presented case, only a diagnostic biopsy was performed. Because of the persistence of clinical symptoms, a cystoscopic examination and biopsy was repeated three times in a two year period. There was no malignancy seen in the repeated biopsies.

Full text



xanthogranulomatous cystitis, xanthogranulomatous urethritis.


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