An alternative synthesis of Azilsartan: an angiotensin II receptor blocker
Curr Issues Pharm Med Sci., Vol. 28, No. 2, Pages 72-76
Srinivas Garaga1,2*, Nimesh C. Misra1, Ambati V. Raghava Reddy1, Koilpillai Joseph Prabahar1,
Chandiran Takshinamoorthy1, Paul Douglas Sanasi2, Raghubabu Korupolu2
1 Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India
2 Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India
This paper provides a description of an alternative, novel and commercially viable process which has been developed for the preparation of Azilsartan, a pro-drug of Azilsartan medoxomil, an angiotensin II receptor blocker. The present work also provides a primary account of the synthesis and characterization of the novel intermediates (6, 7 & 10) of Azilsartan, with their spectral data.
Azilsartan, novel intermediates, synthesis and characterization.