Current Issues of Pharmacy and Medical Sciences

The hepatoprotective activity of the Herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity ...

Curr Issues Pharm Med Sci., Vol. 27, No. 4, Pages 263-266

Daariimaa Khurelbat1, Mandakhnaran Purevkhuu1, Batgerel Luvsansharav2,
Sarantsetseg Bandi2, Davaasuren Tseveen1, Tsetsegmaa Sanjjav1,
Enkhjargal Dorjbal1, Ambaga Miegombo2

1 School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
2 New Medicine” Medical Institute of Mongolia

DOI: 10.1515/cipms-2015-0030

Abstract

The Hepatoprotective activity of the Herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch,  in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet.

The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control.

Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

 

FULL TEXT

Keywords

salivin, carbon tetrachloride, hepatoprotective activity

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