Current Issues of Pharmacy and Medical Sciences

Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review

Curr Issues Pharm Med Sci., Vol. 27, No. 4, Pages Pages 229-233

Urszula Orzedala-Koszel1, Mansur Rahnama1, Michal Lobacz1, Hanna Koszel2

1 Department of Oral Surgery, Medical University of Lublin, 7 Karmelicka, 20-081 Lublin, Poland 
2 Student Research Group, Dept. of Oral Surgery, Medical University of Lublin

DOI: 10.1515/cipms-2015-0021

 

Abstract

Apoptosis is a physiological process that occurs in the human body throughout the entire life span. This process can be seen in the tissues of the stomatognathic system. A disorder in such programmed cell death processes leads to the development of pathological lesions. Among these are inflammation, osteolytic lesions and neoplastic hyperplasia. We put forward that future studies should concentrate on how to use the knowledge of apoptotic processes and their inhibitors in therapeutic processes involving the stomatognathic system.

 

FULL TEXT

Keywords

apoptosis, Bcl-2, Ki-67, p53, follicular cyst, keratocyst

References

  1. Bielak- Żmijewska A.: Resistance to apoptosis mechanisms of neoplastic cells., Kosmos problemy nauk biologicznych., 52,2-3,2003
  2. Edamatsu M., et all.: Apoptosis – related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 99,17,2005
  3. Filip A.: Apoptosis – programmed cell death., Cz I Almamater., 1,46,2003
  4. Filip A.: Apoptosis – programmed cell death., Cz II Almamater., 2,47,2003
  5. Kichi E., et all.: Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts., J Oral Pathol Med., 34,280,2005
  6. Lee J.H., et all.: Dental follicle cells and cementoblasts induce apoptosis of ameloblast- lineage and Hartwig’s epithelial root sheath/ epithelial rests of Malassez cells through the Fas-Fas ligand pathway., Eur J Oral Sci., 29,120,2012
  7. Lin S.K., et all.: Nitric oxide promotes the progression of periapical lesion via inducing macrophage and osteoblast apoptosis., Oral Microbiol Immunol., 24,22,2007
  8. Loyola A. M., et all.: Apoptosis in epithelial cells of apical radicular cysts., International Endodondic Journal., 38, 465, 2005
  9. Matalova E., et all.: Caspase-7 participates in differentiation of cells forming dental hard tissues., Develop. Growth Differ., 615,55,2013
  10. Mitrus I., Missol- Kolka E., Szala S.: Pro-apoptotic genes in gene therapy of neoplasms., Współczesna Onkologia., 5,6,2001
  11. Nagai H., et all.: Inducible nitric oxide synthase and apoptosis related factors in the synovial tissues of temporomandibular joints with internal derangement and osteoarthritis., American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg., 61, 801, 2003
  12. Rahman F., et all.: Analysis of the immuno-expression of Ki-67 and bcl-2 in the pericoronal tissues of impacted teeth, dentinogerous cysts and gingiva using software image analysis., Dent Res. J., 1,10,2013
  13. Rakprasitkul S., et all.: Pathologic changes in the pericoronal tissues of un-erupted third molars., Oral Medicine.,
  14. Rana M.W., et all.: Detection of apoptosis during orthodontic tooth movement in rats., American Journal of Orthodontics and Dentofacial orthopedics., 119,5,2001
  15. Rangiani A., Motahhary P.: Evaluation of bax and bcl2 expression in odotogenic keratocysts and orthokeratinized odontogenic cysts: A comparison of two cysts., Oral Oncology., 2008
  16. Razavi S.M., et all.: The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: An immunohistochemical study., Dent Res. J., 1,9,2012
  17. Rodrigues L.V., et all.: Apoptosis in pulp elimination during physiological root resorption in human primary teeth., Braz. Dent. J., 20, 3, 2009
  18. Suzuki T., et all.: Immunohistochemical analysis of apoptosis-related factors in lining epithelium of radicular cysts., J Oral Patho Med., 34, 46, 2005
  19. Takahashi K., et all.: Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry., Oral Diseases., 320, 5, 1999
  20. Toslos K. I., Kakarantza-Angelopoulou E., Kapranos N.: Immunohistochemical study of bcl-2 protein, Ki-67 antigen and p53 protein in epithelium of glandular odontogenic cysts and dentigerous cysts., J Oral Pathol Med., 29, 44, 2000
  21. Wu T., et all.: Hydrogen Peroxide induces apoptosis in human dental pulp cells via Caspase-9 dependent pathway., JOE.,
  22. Vermelin L., Lecolle S., Septier D. et all: Apoptosis in human and rat dental pulp., Eur J Oral Sci., 547,104,1996

Calendar

July 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31