Current Issues of Pharmacy and Medical Sciences

Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review

Curr Issues Pharm Med Sci., Vol. 27, No. 4, Pages Pages 229-233

Urszula Orzedala-Koszel1, Mansur Rahnama1, Michal Lobacz1, Hanna Koszel2

1 Department of Oral Surgery, Medical University of Lublin, 7 Karmelicka, 20-081 Lublin, Poland 
2 Student Research Group, Dept. of Oral Surgery, Medical University of Lublin

DOI: 10.1515/cipms-2015-0021



Apoptosis is a physiological process that occurs in the human body throughout the entire life span. This process can be seen in the tissues of the stomatognathic system. A disorder in such programmed cell death processes leads to the development of pathological lesions. Among these are inflammation, osteolytic lesions and neoplastic hyperplasia. We put forward that future studies should concentrate on how to use the knowledge of apoptotic processes and their inhibitors in therapeutic processes involving the stomatognathic system.




apoptosis, Bcl-2, Ki-67, p53, follicular cyst, keratocyst


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