Current Issues of Pharmacy and Medical Sciences

Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions

Curr Issues Pharm Med Sci., Vol. 27, No. 4, Pages 213-216

Maria Zuń1, Dorota Dwornicka1, Katarzyna Wojciechowska1, Katarzyna Świąder 1,
Regina Kasperek 1, Marzena Rządkowska2, Ewa Poleszak1

Chair and Department of Applied Pharmacy, Faculty of Pharmacy , Medical University of  Lublin, 1 Chodźki St., 20-093 Lublin, Poland

Chair and Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Unit., Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland

DOI: 10.1515/cipms-2015-0017


In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant  increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.




hydrogen peroxide, urea, stability, activation energy


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