Current Issues of Pharmacy and Medical Sciences

An adverse events potential costs analysis based on Drug Programs in Poland. Dermatology focus

Curr Issues Pharm Med Sci., Vol. 27, No. 3, Pages 183-186

Monika Szkultecka-Dębek1*, Mariola Drozd2, Nina Kiepurska1, Agnieszka Janowska3,
Piotr Paprzycki3, Beata Paluchowska1

1 Dermatology, Military Institute of Medicine, Warsaw, Poland

2 Department of Applied Pharmacy, Medical University of Lublin, Poland

3 Department of Functional Research, Institute of Rural Health in Lublin, Poland

DOI: 10.1515/cipms-2015-0012


The aim of the project, carried out within the Polish Society for Pharmacoeconomics (PTFE), was to estimate the potential costs of treatment of the side effects which (theoretically) may occur as a result of treatments for the selected diseases. This paper deals solely with dermatology related events. Herein, several Drug Programs financed by the National Health Fund in Poland, in 2012, were analyzed. The adverse events were selected based on the Summary of Product Characteristics of the chosen products. We focused the project on those potential adverse events which were defined in SPC as frequent and very frequent. The results are presented according to their therapeutic areas, and in this paper, the focus is upon that which is related to dermatology. The events described as 'very common' had an incidence of ≥ 1/10, and that which is 'common' -  ≥ 1/100, <1 /10. In order to identify the resources used, we, with the engagement of clinical experts, performed a survey. In our work, we employed only the total direct costs incurred by the public payer, based on valid individual cost data in February 2014. Moreover, we calculated the total spending from the public payer's perspective, as well as the patient's perspective, and the percentage of each component of the total cost in detail. The paper, thus, informs the reader of the estimated costs of treatment of side effects related to the dermatologic symptoms and reactions. Based on  our work, we can state that the treatment of skin adverse drug reactions generates a significant cost – one incurred by both the public payer and the patient.




the cost treatment, adverse events, dermatology


  1. Bates D.W. et al.: The cost of adverse drug events in hospitalized patients. JAMA, 277, 4, 1997.
  2. Borovicka J.H. et al.: Economic burden of dermatologic adverse events induced by molecularly targeted cancer agents. Arch Dermatol., 147, 12, 2011. doi: 10.1001/archdermatol.2011.719.
  3. Classen D.C. et al: Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA, 277, 4, 1997.
  4. Dubey A.K. et al.: Dermatological adverse drug reactions due to systemic medications. A review of literature; Journal of Pakistan Association of Dermatologists, 16, 2006.
  5. Koelblinger P. et al.: Skin manifestations of outpatient adverse drug events in the United States: a national analysis. J Cutan Med Surg., 17, 4, 2013.
  6. Pliki parametryzujące. Online: html, Access: 2014.06.20
  7. Rozporządzenie Ministra Zdrowia z 2 kwietnia 2012 r. w sprawie minimalnych wymagań, jakie muszą spełniać analizy uwzględnione we wnioskach o objęcie refundacją i ustalenie urzędowej ceny zbytu oraz o podwyższenie urzędowej ceny zbytu leku, środka spożywczego specjalnego przeznaczenia żywieniowego, wyrobu medycznego, które nie mają odpowiednika refundowanego w danym wskazaniu. Dz. U. 2012, poz. 388
  8. Stausberg J., Hasford J.: Drug-related admissions and hospitalacquired adverse drug events in Germany: a longitudinal analysis from 2003 to 2007 of ICD-10-coded routine data. Health Services Research, 11, 2011.
  9. Szkultecka-Debek M. et al.: Adverse events (AE) cost assessed in Poland based on existing Drug programs – methodology of the project. Curr. Issues Pharm. Med. Sci., 26, 4, 2013.
  10. Ustawa z dn. 12 maja 2011 roku. O refundacji leków, środków spożywczych specjalnego przeznaczenia żywieniowego oraz wyrobów medycznych. Dz. U. 2011 nr 122 poz. 696 z późn. zm.;
  11. Wiśniewska N. et al.: The direct costs of drug-induced skin reactions in Poland. Value in Health, 16, 7, 2013.
  12. Załącznik do Obwieszczenia Ministra Zdrowia z dnia 23 czerwca 2014 r. w sprawie wykazu refundowanych leków, środków spożywczych specjalnego przeznaczenia żywieniowego oraz wyrobów medycznych na dzień 1 lipca 2014 r. Online: Access: 2014.07.01


April 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30