Current Issues of Pharmacy and Medical Sciences

Essential oil composition and variability of Hypericum perforatum L. from wild population in Kosovo

Curr Issues Pharm Med Sci., Vol. 27, No. 1, Pages 51-54

Avni Hajdari1*, Behxhet Mustafa1, Dashnor Nebija2, Albana Kashtanjeva1,
Jarosław Widelski3, Kazimierz Głowniak3, Johannes Novakd4

1 Department of Biology, Faculty of Mathematical and Natural Science, University of Prishtina “Hasan Prishtina”. Mother Theresa st., 10000 Prishtinë, Kosovo
2 Department of Pharmacy, Faculty of Medicine, University of Prishtina “Hasan Prishtina”. St. Bulevardi i Dëshmorëve, 10 000 Prishtinë, Kosovo
3 Department of Pharmacogosy with Medicinal Plants Laboartory, Medical Univeristy of Lublin Chodźki 1 Street, 20-093 Lublin, Poland
4 Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria

DOI: 10.2478/cipms-2014-0013



Aerial parts of Hypericum perforatum L. (Hypericaceae) were collected from five wild populations in Kosovo, with aim to investigate the chemical composition and natural variation of essential oils between wild populations. This species could  be considered of economic potential as it is widespread in Kosovo, on the other hand H. perforatum is one of the best-known medicinal herbs used in Kosovo folk medicine. Essential oils were obtained by steam distillation and analysed by GC-FID and GC-MS. Sixty-seven components were identified. The yields of essential oils differed depending on the population and ranged from 0.04 to 0.26% based on dry weight. The aerial parts of H. perforatum were characterized by the following main constituents: 2-methyl-octane (1.1-15.5%), α-pinene (3.7-36.5%), β-caryophyllene (1.2-12.4%), caryophyllene oxide (3.3-17.7%) and n-tetradecanol (3.6-10.4%). Hierarchical cluster analysis revealed that the concentration of components depends on the origin of the plant populations, thus α-pinene and 2-methyl-octane were present in the highest concentration in population originating from Gjakovë, Prizren and Ferizaj, whereas in the populations originating from Pejë and Prishtinë the most abundant constituents were caryophyllene oxide, β-caryophyllene and n-tetradecanol. Further investigation is needed to establish the natural variability and chemopolymorphism of this species in the territory of Kosovo, which should be supported by molecular level analyses.


Full Text


essential oil, Hypericum perforatum, Kosovo, natural variability


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