Current Issues of Pharmacy and Medical Sciences

FAPA mass spectrometry of hydroxychalcones. Comparative studies with classical methods of ionization

Curr Issues Pharm Med Sci., Vol. 27, No. 1, Pages 27-31

Marek Smoluch1*, Grażyna Bartkowiak2, Edward Reszke3, Wojciech Lechowicz4,
Jerzy Silberring1,5, Grzegorz Schroeder2

 

AGH University of Science and Technology, Department of Biochemistry and Neurobiology, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30-059 Kraków, Poland

Adam Mickiewicz University in Poznań, Faculty of Chemistry, Umultowska 89b, 61-614 Poznań, Poland

ERTEC-Poland, Rogowska 146/5, 54-440 Wrocław, Poland

Institute of Forensic Research, Westerplatte 9, 31-033 Kraków, Poland

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowskiej St. 34, 41-819 Zabrze, Poland


DOI: 10.2478/cipms-2014-0008

Abstract

In this paper we are focused on analysis of hydroxychalcones, i.e. 2’ –hydroxychalcone, 3’ –hydroxychalcone and 4’ –hydroxychalcone, by the Flowing Atmospheric Pressure Afterglow mass spectrometry (FAPA-MS), and on comparison of the obtained data with other classical methods including ESI-MS, APCI, MALDI, and GC/EI-MS. The paper is presenting fragmentation pathways of both positive-, and negative hydroxychalcone ions. Tested compounds were characterized by comparison of the results (signals m/z and relative intensities) from the five mass spectrometry techniques, showing very good utility of FAPA method for fast and easy analysis of the low molecular weight compounds. Moreover, FAPA does not require a time-consuming derivatization, nor search for a suitable solvent or matrix, often incompatible with various ion sources. 

 

Full Text

Keywords

FAPA, mass spectrometry, hydroxychalcones

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