Current Issues of Pharmacy and Medical Sciences

Review on analgesic effect of co-administrated ibuprofen and caffeine

Curr Issues Pharm Med Sci., Vol. 27, No. 1, Pages 10-13


Department of Applied Pharmacy, Medical University of Lublin, Poland

Department of Organic Chemistry, Medical University of Lublin, Poland

DOI: 10.2478/cipms-2014-0003


Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.


Full Text


analgesic, caffeine, ibuprofen, tablets


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