Current Issues of Pharmacy and Medical Sciences

Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) and high sensitivity C-reactive protein (hsCRP) levels, and extends coronary

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 453-456

BARTOSZ ZIĘBA, ELZBIETA KIMAK

Department of Laboratory Diagnostics Medical University of Lublin


DOI: 10.12923/j.2084-980X/26.4/a.23

Abstract

A serum lipid profiles high sensitivity C-reactive protein (hsCRP) levels are established risk factors for atherosclerosis, and a powerful predictor of future myocardial infarction or cardiac death among apparently healthy individuals. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is know but not as cardiovascular risk factor. The aim of this study was to investigate serum Lp-PLA2 activity and arterial stiffness and others atherosclerosis biochemistry markers in patients with stable coronary artery disease. We studied 17 consecutive patients (women, n=6 and men, n=11), mean age was 61 years, with stable coronary artery disease (CAD), hospitalized in the Department of Cardiology Cardinal Wyszyński Hospital in Lublin in 2012 and 2013. The patients with acute and chronic kidney disease, liver diseases, active autoimmune disease, malignancy, thyroids diseases or alcohol disease were excluded from the analysis. The patients had worse laboratory parameters than the reference group. We showed significant positive correlation between serum level LpPLA2 and extends coronary disease in patients who had upper LpPLA2 levels in year observation. We concluded that dyslipidemia together with hsCRP and Lp-PLA2 and monitoring of its levels may be good markers to predict ACS or other CAD events and vessels lesions in asymptomatic patients with CAD. However, these results require further studies.

 

Keywords

lipoprotein-associated phospholipase A2, high sensitivity C-reactive protein, coronary artery disease

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