Current Issues of Pharmacy and Medical Sciences

The interferon production and 2',5'-oligoadenylate-synthetase activity in rat spleen lymphocytes at hypoacidity evoked by...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 398-400

Irina Kompanets, Alexander Korotkiy, Taras Karpovets, Ludmila Ostapchenko,
Sergiy Pilipenko, Dmitriy Yankovskiy

Department of Biochemisrtry of Educational and Scientific Centre "Institute of Biology" Taras Shevchenko National University of Kyiv, Ukraine


DOI: 10.12923/j.2084-980X/26.4/a.10

Abstract

The IFN production by rat spleen lymphocytes was shown to increase by 2.5 times in comparison to control against a background of hypoacidity evoked by 28-days of OM treatment (14 mg/kg). The activity of IFN-induced enzyme 2',5'-OAS declined by 16 % in these cells. The simultaneous administration of multiprobiotic SYM and OM resulted in IFN titer increase in comparison to hypoacidic animals. The 2',5'-OAS activity in spleenocytes didn’t change. SYM displayed interferonogenic properties via gastric microflora normalization and suppressing inflammation.

Keywords

interferon, 2',5'-oligoadenylate-synthetase, omeprayole, multiprobiotic

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