Current Issues of Pharmacy and Medical Sciences

Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment ...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 390-392

Iryna Ferents, Iryna Brodyak, Maryana Lyuta, Natalia Klymyshyn,
Volodymyra Burda, Natalia Sybirna

Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine

DOI: 10.12923/j.2084-980X/a.08

 

Abstract

Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment with agmatine

 

Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both α (2,3)- and α(2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular α(2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.

Keywords

experimental diabetes mellitus, leukocyte, membrane glycoconjugates, sialic acid, agmatine

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