Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment ...
Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 390-392
Iryna Ferents, Iryna Brodyak, Maryana Lyuta, Natalia Klymyshyn,
Volodymyra Burda, Natalia Sybirna
Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment with agmatine
Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both α (2,3)- and α(2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular α(2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.
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experimental diabetes mellitus, leukocyte, membrane glycoconjugates, sialic acid, agmatine
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