Arginase/nitric oxide synthase regulatory mechanism of cells under the action of trigger factors that cause reactive arthritis
Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 382-384
Oksana Melnyk, Olena Kornijchuk, Zinovy Vorobets, Mariya Tymkiv, Andriy Zakalskyy
Danylo Halytsky Lviv National Medical University, Ukraine
On the basis of the research it can be argued that the determination of the enzymatic activity of arginase and NO-synthase of peripheral blood lymphocytes gives a qualitative informative assessment on the functioning of the immune cells, as changes in the activity of arginase reflect the NO metabolism. In the research, the optimal conditions of arginase reaction were determined and some of kinetic parameters of arginase were established. The significant growth of arginase activity (3.3 times) and iNO-synthase activity (3.8 times) in peripheral blood lymphocytes in patients with reactive arthritis compared with practically healthy donors was shown.
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arginase, L-arginine, NO-synthase, reactive arthritis, lymphocytes
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