Current Issues of Pharmacy and Medical Sciences

Metabolic profile and morpho-functional state of the liver in rats with glutamate-induced obesity

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 379-381

Maryana Kondro1, Galyna Mykhalchyshyn2, Petro Bodnar2, Nazarii Kobyliak2, Tetyana Falalyeyeva3

1Danylo Halytsky Lviv National Medical University, Ukraine,
2National Bogomolets Medical University, Ukraine,
3Taras Shevchenko National University of Kyiv, Ukraine


DOI: 10.12923/j.2084-980X/26.4/a.05

Abstract

The aim of our study was to investigate effects of monosodium glutamate (MSG) neonatal treatment on metabolic profile and liver morpho-functional state in rats at 16-weeks of age. Our study confirms previously reported data that neonatal treatment with MSG, administered by subcutaneous injection, is able to induce obesity without hyperphagia, which is diagnosed by high Lee index and characterized by small corporal weight and naso-anal length. It was established that MSG neonatal treatment induced metabolic changes at 16 weeks of age, which manifested as disproportional laying of fat deposits with the development of visceral obesity. The level of adiponectin was decreased after MSG neonatal treatment. Also, we showed development of dyslipidemia and non-alcoholic fatty liver disease and impairment sensitivity of peripheral tissue to insulin.

Keywords

monosodium glutamate, obesity, metabolic syndrome, non-alcoholic steatohepatosis, adiponectin

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