Current Issues of Pharmacy and Medical Sciences

Monitoring of liver function in patients with fatty liver disease in combination with coronary heart disease and type 2 diabetes

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 376-378

Krystyna Aksentiychuk, Natalye Kurlyak, Eugene Sklyarov

Department of Therapy, Faculty of Postgraduate Education, Danylo Halytsky Lviv National Medical University, Ukraine


DOI: 10.12923/j.2084-980X/26.4/a.04

Abstract

The aim of the study was to examine the liver detoxification function by comparing a 13C- methacethine breath test, with a Forns formula and with liver transaminases in patients with coronary heart disease and type 2 diabetes mellitus in combination with nonalcoholic fatty disease Comparisons of the rates of metabolism (p <0.01) between cumulative dose at 40 minutes (p <0.01) with those at 120 minutes (p <0.01), in two groups of patients displayed more signs of steatohepatitis than signs of steatosis. Use of the 13C-methacetine test to diagnose pathological changes in the liver in the early stages of NAFLD (steatosis, steatohepatitis) is positively correlated with the Forns formula. It is likely to find fibrosis of the liver when Forns formula is over 4.25, 13C-breath test at least 10%, lower levels of ALT and bilirubin, and elevated triglycerides contrary.

Keywords

nonalcoholic fatty liver disease, steatosis, steatohepatitis, fibrosis, 13C- methacetine breathe test, Forns formula, ultrasonography

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