Current Issues of Pharmacy and Medical Sciences

Oxidizing modification of proteins in case of a burn injury in rats against the topical treatment with new wound healing prepara

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 372-375

Yaroslava Butko1, Oksana Tkacheva1, Tatyana Gorbach2

National University of Pharmacy, Kharkov, Ukraine

Kharkov National Medical University, Kharkov, Ukraine


DOI: 10.12923/j.2084-980X/26.4/a.03

Abstract

A significant increase in the degree of the oxidizing modification of proteins in rats after the reproduction of the third-degree burns was established. In the course of the treatment, positive changes in aldehydephenylhydrazones and ketophenylhydrazones indices and their restoration to the level of the intact control were received, indicating the inactivation of free radical and peroxide compounds under the influence of wound healing preparations, as opposed to the animals that did not receive treatment. The further study of the influence of new wound healing drugs on the state of the antioxidant system and lipid peroxidation in order to establish their mechanisms of reparative action is promising.

Keywords

a burn injury, oxidizing modification of proteins, wound healing preparations

References

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