Current Issues of Pharmacy and Medical Sciences

Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 4, Pages 369-371

Berta Borzenko, Elena Bakurova, Ksenia Mironova

M. Gorky Donetsk National Medical University , Department of Chemistry, Ukraine

DOI: 10.12923/j.2084-980X/26.4/a.02


Patients with cancer of stomach, colon cancer and rectum showed an increase in the thymidine kinase, 5'–nucleotidase of adenylate, adenosine deaminase activities and a decrease in the thymidine phosphorylase activity, which can cause  DNA biosynthesis and increase of proliferation. The lymphocyte 5'–nucleotidase of adenylate, adenosine deaminase activities are associated with cellular dysfunction and can be used as a biochemical tests of it. 


cancer, thymidine phosphorylase, thymidine kinase, 5′-nucleotidase of AMP, adenosine deaminase, blood serum, lymphocytes 


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