Pathophysiological aspects of the pancreas function in rats with monosodium glutamate-induced obesity
Curr Issues Pharm Med Sci Vol. 26, No. 4, Pages 365-368
Ivan Leschenko1, Victor Shevchuk1, Oleksandr Savcheniuk2, Tetyana Falalyeyeva2, Tetyana Beregova2
1 Bogomolets National Medical University, Ukraine
2 Taras Shevchenko National University of Kyiv, Ukraine
Our study demonstrates that neonatal treatment with monosodium glutamate (MSG) leads to the development of visceral obesity in adult rats. In rats’ pancreas of both sexes massive edema and inflammation were found, which are characteristic of acute pancreatitis. Marked intralobular and perivascular lipomatosis was also found. There was also marked leukocyte infiltration in rats with MSG-induced obesity. Morphometric analysis confirmed pathological changes in pancreatic tissue. The level of blood amylase, lipase and pancreatic amylase was increased by 92% (p<0.001), 312% (p<0.001) and 162% (p<0.001). So, neonatal treatment with MSG leads to the development of pancreatitis in adulthood of rats. We concluded that the development of pancreatitis in rats with MSG-induced obesity is the result of increase of synthetic and secretory processes in pancreatic cells.
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