Current Issues of Pharmacy and Medical Sciences

Dimethicone impact on aeration of suppository mass in Unguator mixing machine

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 339-343

ANDRZEJ MAREK WINNICKI, DANUTA PARTYKA, KATARZYNA JACHOWICZ, TOMASZ MACHEROWSKI,
ŁUKASZ MARCHWIŃSKI, PAULINA NĘDZA, MARTYNA STEBNICKA, JOANNA SULEJEWSKA

Chair of Pharmaceutical Technology, Faculty of Pharmacy, Ludwig Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń

DOI: 10.12923/j.2084-980X/26.3/a.22

 

Abstract

Suppository mass foaming is an important technological problem when making suppositories in an Unguator mixing machine that
has an impact on the final quality and the decreased content of an active ingredient in suppositories. Dimethicone is commonly
used as antifoam reducing the surface tension of liquid, which forms walls of gas bubbles. The study shows that using dimethicone
results in the reduction of aeration of the suppository mass from 10.5% to 20.1%.
 

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Keywords

aeration, suppository, dimethicone, Unguator mixing machine

References

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