Current Issues of Pharmacy and Medical Sciences

Primary small cell neuroendocrine carcinoma of the esophagus

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 335-338


Department of Clinical Pathomorphology, Medical University of Lublin, Poland
2nd Department of General Surgery, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.3/a.21



Primary small cell neuroendocrine carcinoma of the esophagus is a very rare entity characterized by poor prognosis. Two new cases
with clinicopathological characteristics are presented. In both female patients aged 62 and 66 who suffered from dysphagia for a few
months, subtotal esophagectomy with lymph nodes dissection was performed. The final diagnosis was based on the pathological
examination of surgical specimens. The morphology of tumors was typical with additional squamous cell carcinoma component in
one case. Characteristic neuroendocrine granules were also revealed in electron microscope. Neoplastic cells were positive for
pancytokeratin, chromogranin A and synaptophysin. Infiltration into the esophageal adventitia with vessel invasion and
involvement of multiple regional lymph nodes was observed. The patients have died respectively nine and four months after the

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esophagus, small cell carcinoma, neuroendocrine tumor, neuroendocrine carcinoma


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