Current Issues of Pharmacy and Medical Sciences

Primary small cell neuroendocrine carcinoma of the esophagus

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 335-338

DOROTA LEWKOWICZ1, AGNIESZKA FRONCZEK1, ANDRZEJ DĄBROWSKI2, JUSTYNA SZUMIŁO1

Department of Clinical Pathomorphology, Medical University of Lublin, Poland
2nd Department of General Surgery, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.3/a.21

 

Abstract

Primary small cell neuroendocrine carcinoma of the esophagus is a very rare entity characterized by poor prognosis. Two new cases
with clinicopathological characteristics are presented. In both female patients aged 62 and 66 who suffered from dysphagia for a few
months, subtotal esophagectomy with lymph nodes dissection was performed. The final diagnosis was based on the pathological
examination of surgical specimens. The morphology of tumors was typical with additional squamous cell carcinoma component in
one case. Characteristic neuroendocrine granules were also revealed in electron microscope. Neoplastic cells were positive for
pancytokeratin, chromogranin A and synaptophysin. Infiltration into the esophageal adventitia with vessel invasion and
involvement of multiple regional lymph nodes was observed. The patients have died respectively nine and four months after the
operation.

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Keywords

esophagus, small cell carcinoma, neuroendocrine tumor, neuroendocrine carcinoma

References

  1. Bosman F.T. et al. (red.): WHO classification of tumours of the digestive system. IARC Press, Lyon 2010.
  2. Casas F., Ferrer F., Farrus B.: Primary small cell carcinoma of the esophagus. A review of literature with emphasis on therapy and prognosis. Cancer, 89, 1366, 1997.
  3. Craig S.R. et al.: Primary small cell cancer of the oesophagus, J. Thorac. Cardiovasc. Surg., 109, 284, 1995.
  4. Klöppel G.: Epidemiology, tumor biology and histopathological classification of nuroendocrine tumours of the gastrointestinal tract. Best Pract. Res. Clin. Gastroenterol., 19, 507, 2005.
  5. Ku G.Y. et al.: Small-cell carcinoma of the esophagus and gastroesophageal junction: rewiew of the Memorial Sloan-Kettering experience. Ann. Oncol., 19, 533, 2008.
  6. Mc Fadden D.W. et al.: Primary small cell carcinoma of the esophagus. Ann. Thorac. Surg., 47, 477, 1989.
  7.  Mc Keown F.: Oat cell carcinoma of the esophagus. J. Pathol. Bacteriol., 64, 889, 1952.
  8. Pantvaidya M.S. et al.: Small cell carcinoma of the esophagus: Tata Memorial Hospital experience. Ann. Thorac. Surg., 74, 1924, 2002.
  9. Saw E.C. et al.: Synchronous primary neuroendocrine carcinoma and adenocarcinoma in Barrett’s esophagus. J. Clin. Gastroenterol., 24, 116, 1997.
  10. Shimoda T. et al.: Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documentating a complete response. Jpn. J. Clin. Oncol., 36, 109, 2006.
  11. St Martin M.C., Chejfec G.: Barrett esophagus-associated small cell carcinoma. Arch. Pathol. Lab. Med., 123, 1123, 1999.
  12. Szumiło J. et al.: Small cells carcinoma of the rectum. Ann. Univ. Mariae Curie Skłodowska Med. [Sectio D], 61, 321, 2006.
  13. Takubo K. et al.: Primary undifferentiated small cell carcinoma of the esophagus. Hum. Pathol., 30, 216, 1999.
  14. Terada T.: Small cell neuroendocrine carcinoma of the esophagus: report of 6 cases with immunohistochemical and molecular genetic analysis of KIT and PDGFRA. Int. J. Clin. Exp. Pathol., 6, 485, 2013.
  15. Yamashita H. et al.: Concurent chemoradiation alone with curative intent for limited-disease small cell esophageal cancer in nine Japanese patients. Dis. Esoph., 22, 113, 2009.
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