Current Issues of Pharmacy and Medical Sciences

Biological activities of Salvia L. species

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 326-330


Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin

DOI: 10.12923/j.2084-980X/26.3/a.19



Salvia officinalis L. is one of the most widespread species, and because of this, is the most popular among other Salvia L. However, there are many other Salvia species with the long history of use in the treatment of a variety of disorders. The dried root of S. miltiorrhiza Bunge is one of the most popular herbal traditional medicines in Asian countries, while a mixture of leaves of S. fulgens Cav. and S. microphylla Kunth. is a traditional Mexican medicine, called ‘mirto’, and used for stomach ailments. Despite the extensive traditional use of many Salvia species around the world, the phytochemical and biological studies concerning sage are still very popular. The review aims to show recent research results concerning biological activities of Salvia species, and some of them, e.g. anticholinesterase, neuroprotective, anticancer, antiviral, anti-inflammatory, and antioxidant activity were summarized.

Files to download


Salvia, pharmacological studies, chemical constituents, essential oils, extracts


  1. Aruoma O.I.: Free radicals, oxidative stress and anti-oxidants in human health and disease. J. Am. Oil Chem. Soc., 75, 199,1998.
  2. Baj T., Ludwiczuk A, Sieniawska E. et al.: GC-MS analysis of essential oils from Salvia officinalis L.: A comparison of extraction methods of the volatile components. Acta Pol. Pharm., 70, 35, 2013.
  3. Baricevic D., Sosa S., Della L.R. et al.: Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursalic acid. J. Ethnopharmacol., 75, 125, 2001.
  4. Bylac S., Racine P.: Inhibition of 5-lipoxygenase by essential oils and other natural fragrant extracts. Int. J. Aromather., 13, 138, 2003.
  5. Esmaeili A., Rustaiyan A., Nadimi M.: Chemical composition and antibacterial activity of essential oils from leaves, stems and flowers of Salvia reuterana Boiss. grown in Iran. Nat. Prod. Res., 22, 516, 2008.
  6. Foster S., Tyler V.E. (1999) Tyler’s honest herbal. A sensible guide to the use of herbs and related remedies. The Haworth Herbal Press. New York, London; p.327
  7. Fraternale D., Giamperi L., Bucchini A. et al.: Composition and antifungal activity of essential oil of Salvia sclarea from Italy. Chem. Nat. Compd., 41, 604, 2005.
  8. Gono-Bwalya A. (2003) The chemotaxonomy and biological activity of Salvia stenophylla (Lamiaceae) and related taxa. M.Sc. Dissertation. University of the Witwatersrand, South Africa.
  9. Grzegorczyk I., Matkowski A., Wysokinska H.: Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L. Food Chem., 104, 536, 2007.
  10. Hristova Y., Gochev V., Wanner J. et al.: Chemical composition and antifungal activity of essential oil of Salvia sclarea L. from Bulgaria against clinical isolates of Candida species. J. BioSci. Biotech., 2, 39, 2013.
  11. Jeong H., Sung M., Kim Y. et al.: Anti-inflammatory activity of Salvia plebeia R. Br. leaf through heme oxygenase-1 induction in LPS-stimulated RAW264.7 macrophages. J. Korean Soc. Food Sci. Nutr., 41, 888, 2012.
  12. Jirovetz L., Wlcek K., Buchbauer G. et al.: Antifungal activities of essential oils of Salvia lavandulifolia, Salvia officinalis and Salvia sclarea against various pathogenic Candida species. J. Essen. Oil Bear. Pl., 10, 430, 2007.
  13. Kamatou G.P.P. (2006) Indigenous Salvia species – an investigation of their pharmacological activities and phytochemistry. Ph.D. Thesis. University of the Witwatersrand, South Africa.
  14. Kamatou G.P.P., Makunga N.P., Ramogala W.P.N., Viljoen A.M.: South African Salvia species: A review of biological activities and phytochemistry. J. Ethnopharmacol., 119, 664, 2008.
  15. Kamatou G.P.P., Viljoen A.M., Gono-Bwalya A.B. et al.: The in vitro pharmacological activities and chemical investigation of three South African Salvia species. J. Ethnopharmacol., 102, 382, 2005.
  16. Kamatou G.P.P., Viljoen A.M., Van Zyl R.L. et al.: The antimalarial and cytotoxic effects of solvent extracts of South African Salvia species and isolated compounds from S. radula. South African J. Bot., 74, 238, 2008.
  17. Kontogianni V.G., Tomic G., Nikolic I. et al.: Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem., 136, 120, 2013.
  18. Liu L., Jia J., Zeng G. et al.: Studies on immunoregulatory andante-tumor activities of a polysaccharide from Salvia miltiorrhiza Bunge. Carbohydr. Polym., 92, 479, 2013.
  19. Loizzo M.R., Menichini F., Tundis R. et al.: In vitro biological activity of Salvia leriifolia Benth essential oil relevant to the treatment of Alzheiner’s disease. J. Oleo Sci., 58, 443, 2009.
  20. Moharram F.A., Marzouk M.S., El-Shenawy S.M. et al.: Polyphenolic profile and biological activity of Salvia splendens leaves. J. Pharm. Pharmacol., 64, 1678, 2012
  21. Oboh G., Henle T.: Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro. J. Med. Food, 12, 77, 2009.
  22. Orhan I.E., Senol F.S., Ercetin T. et al.: Assessment of anticholinesterase and antioxidant properties of selected sage (Salvia) species with their total phenol and flavonoid contents. Ind. Crop Prod., 41, 21, 2013.
  23. Park O.K., Choi J.H., Park J.H. et al.: Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient celebral ischemic damage. Fitoterapia, 83, 1666, 2012.
  24. Park S.H., Kim J.L., Kang M.K. et al.: Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages. Int. J. Mol. Med., 30, 1105, 2012.
  25. Peana A.T., Moretti M.D.L., Juliano C.: Chemical composition and antimicrobial action of the essential oils of Salvia desolea and S. sclarea. Planta Med., 65, 752, 1999.
  26. Perry N., Court G., Bidet N. et al.: Cholinergic activities of European herbs and potential for dementia therapy. J. Geriatr. Psychiatry, 11, 1063, 1996.
  27. Pierozan M.K., Pauletti G.F., Rota L. et al.: Chemical characterization  and antimicrobial activity of essential oils of Salvia L. species. Ciênc. Tecnol. Aliment., 29, 764, 2009.
  28. Robbers J.E., Tyler V.E. (1999) Tyler’s herbs of choice. The therapeutic use of phytomedicinals. The Haworth Herbal Press. New York, London; p. 227.
  29. Savelev S.U., Okello E.J., Perry E.K.: Bytyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytother. Res., 18, 315, 2006.
  30. Segrua-Campos M.R., Salazar-Vega I.M., Chel-Guerrero L.A. Betancur-Ancona D.A.: Biological potential of chia (Salvia hispanica L.) protein hydrolysates their incorporation into functional foods. LWT – Food Sci. Technol., 50, 723, 2013.
  31. Šmidling D., Mitić-Ćulafić D., VukoviC-Gačić B. et al.: Evaluation of antiviral activity of fractionated extracts of sage Salvia officinalis L. Arch. Biol Sci., 60, 421, 2008.
  32. Tepe B., Sokmen M., Akpulat H.A., Sokmen A.: Screening of the antioxidant potentials of six Salvia species from Turkey. Food Chem., 95, 200, 2006.
  33. Üstün Alkan F., Esen Gürsel F., Ateş A. et al.: Protective effects of Salvia officinalis extracts against cyclophosphamide-induced genotoxicity and oxidative stress in rats. Turk. J. Vet. Anim. Sci., 36, 646, 2012.
  34. Vázques-Ovando A., Rosado-Rubio G., Chel-Guerrero L., Betancur-Ancona D.:  Physicochemical properties of a fibrous fraction from chia (Salvia hispanica L.). LWT – Food Sci. Technol., 42, 168, 2009.
  35. Wang R., Yu X.Y., Guo Z.Y. et al.: Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling. J. Ethnopharmacol., 144, 592, 2012.
  36. Wolski T., Ludwiczuk A., Mardarowicz M.: Composition of essential oil and its content in leaves and gallenic preparations made of sage (Salvia officinalis L.). Annales UMCS sec. EEE, 8, 85, 2000.
  37. Wu Y.B., Ni Z.Y., Shi Q.W. et al.: Constituents from Salvia species and their biological activities. Chem. Rev., 112, 5967, 2012.
  38. Zeng X., Li Z., Sun L. et al.: Recovery from rat sciatic nerve injury in vivo through the use of differentiated MDSCs in vitro. Exp. Ther. Med., 5, 193, 2013.
  39. Zhang N., Kang T., Xia Y. et al.: Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. Eur. J. Pharmacol., 697, 32, 2012.
  40. Zhang Z.F., Chen H.S., Peng Z.G. et al.: A potent anti-HIV polyphenol from Salvia yunnanensis. J. Asian Nat. Prod. Res., 10, 252, 2008.
  41. Zhang Z.F., Peng Z.G., Gao L. et al.: Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. J. Asian Nat. Prod. Res., 10, 391, 2008.
prev next



April 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30