Current Issues of Pharmacy and Medical Sciences

Blood serum Vitamin D status evaluated in healthy people

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 317-320


Department of Biochemistry Diagnostics, Medical University of Lublin

DOI: 10.12923/j.2084-980X/26.3/a.17



The purpose of the study was to evaluate the status of vitamin D in healthy subjects. Vitamin D level was determined on the basis of blood serum 25(OH)D concentrations, taking into account the time of blood collection and age. Moreover, it was to find correlations between serum concentrations of: 25(OH)D, calcium, inorganic phosphates and serum alkaline phosphatase (ALP) activity. The randomized study was carried out on a group of 40 healthy subjects. Each person had venous blood samples drawn twice: from 6 March, 2012 to 15 March, 2012 and from 25 June, 2012 to 6 July, 2012. The results found the majority of subjects had lowered serum 25(OH)D concentrations compared to the reference range determined in the winter months of little insolation and in the summer months of much insolation. In the summer the blood serum concentration of 25(OH)D and ALP activity were statistically significantly higher in comparison with the winter and spring. The concentration of 25(OH)D was not statistically significantly related to age, concentrations of Ca, inorganic phosphates and ALP activity.

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vitamin D, calcium, inorganic phosphates, ALP, healthy humans serum


  1. Andersen R. et al.: Teenage girls and elderly women living in northern Europe have low winter vitamin D status. Eur. J. Clin. Nutr., 59, 533, 2005.
  2. Bhattoa H. et al.: A prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal women. Osteoporos. Int., 15, 447, 2004.
  3. Bogaczewicz J. et al.: Analysis of the dynamics of vitamin D status in the population of the Lodz region- a preliminary report. Post. Dermatol. i Alergol., 28, 170, 2011.
  4. Czech-Kowalska J. et al.: High prevalence of neonatal vitamin D deficiency- rationale for reevaluation of vitamin D supplementation during pregnancy. Arch. Perinat. Med., 14, 18, 2008.
  5. Czech-Kowalska J. et al.: Profilaktyka niedoborów witaminy D. Endokrynol. Diabetol., 19, 57, 2011.
  6. Doroszko A., Gronowicz E., Niedzielska E.: Aktualne spojrzenie na zalecenia dotyczące dawkowania cholekalcyferolu. Gastroenetrol. Pol., 15, 255, 2008.
  7. Fassi J. et al.: Seasonal variations in 25-hydroxyvitamin D in young and elderly in population in Buenos Aires City. Med. B. Aires, 63, 215, 2003.
  8. Figura B.: Witamina D. Świat Farmacji, 10, 12, 2010.
  9. Hill T. et al.: Seasonal changes in vitamin D status and bone turnover in healthy Irish postmenopausal women. Int. J. Vitam. Nutr. Res., 77, 320, 2007.
  10. Hypponen E., Power C.: Hypovitaminosis D in British adults at age 45 years: nationwide cohort study of dietary and lifestyle predictors. Am. J. Clin. Nutr., 85, 860, 2007.
  11. Karalus J., Chlebna-Sokół D.: Profilaktyka niedoboru witaminy D. Świat Med. i Farm., 6, 34, 2010.
  12. Karczmarewicz E. et al.: Witamina D - standardy diagnostyczne, kliniczna interpretacja oznaczeń. Terapia, 5, 47, 2008.
  13. Kashi Z. et al.: Vitamin D deficiency prevalence in summer compared to winter in a city with high humidity and a sultry climate. Pol. J. Endocrinol., 62, 249, 2011.
  14. Marcinowska-Suchowierska E., Kozłowska-Wojciechowska M., Filipiak K.: Suplementacja witaminy D u ludzi dorosłych. Terapia, 10, 53, 2010.
  15. Marcinowska-Suchowierska E., Walicka M.: Niedobór witaminy D- narastający problem społeczny. Fam. Med. Prim. Care Rev., 11, 691, 2009.
  16. Napiórkowska L., Budlewski T., Jakubas-Kwiatkowska W.: Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland. Pol. Arch. Med.  Wewn., 119, 699, 2009.
  17. Napiórkowska L., Franek E.: Rola oznaczania witaminy D w praktyce klinicznej. Chor. Serca Naczyń, 6, 203, 2009.
  18. Pasco J. et al.: Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: the Geelong osteoporosis study. J. Bone Miner. Res., 19, 752, 2004.
  19. Stróżecki P. et al.: Roczny profil gospodarki wapniowo-fosforanowej u chorych hemodializowanych z wtórną nadczynnością przytarczyc. Pol. Arch. Med. Wewn., 3, 867, 2002.
  20. Tuchendler D., Bolanowski M.: Sezonowość zmian stężeń witaminy D w organizmie człowieka. Endokrynol. Otyłość Zaburzenia Przemiany Materii, 6, 36, 2010.
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