Current Issues of Pharmacy and Medical Sciences

The effect of selenium supplementation in organic and in organic form on oxidant balance in rat heart and femoral muscle

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 287-291

IRENA MUSIK, MAŁGORZATA KIEŁCZYKOWSKA, JOANNA KOCOT

Chair and Department of Medical Chemistry, Medical University of Lublin, Poland


DOI: 10.12923/j.2084-980X/26.3/a.10

Abstract

Total antioxidant status (TAS), activity of antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GPx), concentrations of non-enzymatic antioxidants - ascorbic acid (AA) and reduced glutathione (GSH) as well as concentration of lipid peroxidation marker - malonyldialdehyde (MDA) were determined in heart and femoral muscle of rats receiving different selecompounds (inorganic selenite and organic selenosemicarbazide of chain structure and selenazoline of ring structure). Chain selenosemicarbazide markedly decreased TAS values vs. control without Se-supplementation in heart. GPx was significantly depressed vs. control in heart of animals receiving organic selenium. Ring selenazoline decreased heart AA, whereas selenosemicarbazide increased heart GSH. Inorganic selenite diminished femoral muscle GSH. Selenium supplementation distinctly inhibited process of lipid peroxidation - MDA was decreased in Se-given animals, particularly in heart. As organic ring selenocompound depressed heart MDA to the highest degree, did not impair total antioxidant status and caused no disturbance of antioxidant barrier in femoral muscle, it could be suggested that further research may reveal possibilities of its application as a Se-supplement.
 

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Keywords

selenium, rats, antioxidant barrier, lipid peroxidation

References

  1. Bertinato J. et al.: Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues. Nutr. J., 6, 7, 2007.
  2. Bradford M.M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248, 1976.

  3. Briens M. et al.: Comparative study of a new organic selenium source v. seleno-yeast and mineral selenium sources on muscle selenium enrichment and selenium digestibility in broiler chickens. Br. J. Nutr., 11, 1, 2013.
  4. Chen Y.J. et al.: Effect of dietary vitamin E and selenium supplementation on growth, body composition, and antioxidant defense mechanism in juvenile largemouth bass (Micropterus salmoide) fed oxidized fish oil. Fish. Physiol. Biochem., 39, 593, 2013.

  5. Cui J. et al.: Correlation between oxidative stress and L-type calcium channel expression in the ventricular myocardia of selenium-deficient mice. Int. Med. Res., 40, 1677, 2012.

  6. Ghazi Harsini S. et al.: Effects of Dietary Selenium, Vitamin E, and Their Combination on Growth, Serum Metabolites, and Antioxidant Defense System in Skeletal Muscle of Broilers Under Heat Stress. Biol. Trace Elem. Res., 148, 322, 2012.

  7. Humann-Ziehank E. et al.: Comparing functional metabolic effects of marginal and sufficient selenium supply in sheep. Trace Elem. Med. Biol., 2013

  8. http://dx.doi.org/10.1016/j.jtemb.2013.03.003

  9. Juniper D.T. et al.: Effect of dietary supplementation with selenium-enriched yeast or sodium selenite on selenium tissue distribution and meat quality in beef cattle. J. Anim. Sci., 86, 3100, 2008.
  10. Juniper D.T., Betin G.: Effects of dietary selenium supplementation on tissue selenium distribution and glutathione peroxidase activity in Chinese Ring necked Pheasants. Animal, 7, 562, 2013.
  11. Ledwożyw A. et al.: The relationships between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin. Chim. Acta, 155, 275, 1986.

  12. Manati W. et al.: Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit. Hum. Exp. Toxicol., 28, 461, 2009.

  13. Marković R. et al.: Effects of selenium supplementation as sodium selenite or selenized yeast   and different amounts of vitamin E on selenium and vitamin E status of broilers. Acta Vet. (Beograd), 58, 369, 2008.
  14. Metes-Kosik N. et al: Both Selenium Deficiency and Modest Selenium Supplementation Lead to Myocardial Fibrosis in Mice via Effects on Redox-Methylation Balance Mol. Nutr. Food Res., 56, 1812, 2012.

  15. Musik I. et al.: Comparison of selenium distribution in mice organs after the supplementation with inorganic and organic selenium compound selenosemicarbazide. Ann. Univ. Mariae Curie Sklodowska Med., 57, 15, 2002.
  16. Musik I. et al.: Influence of different forms of selenium supplementation on superoxide dismutase activity and total antioxidant status in rats. Ann. Univ. Mariae Curie Sklodowska Pharm., 22, 95, 2009.
  17. O´Grady M.N. et al.: Effects of dietary supplementation with vitamin E and organic selenium on the oxidative stability of beef. J. Anim. Sci., 79, 2827, 2001.
  18. Orun I. et al.:  Antioxidative role of selenium on some tissues of (Cd2+ , Cr3+)-induced rainbow trout. Ecotoxicol. Environ. Saf., 71, 71, 2008.
  19. Pinto A. el al.: Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs. J. Inorg. Biochem., 114, 47, 2012.
  20. Prigol M., Luchese C., Nogueira C.W.: Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice. Cell Biochem. Funt., 27, 216, 2009.
  21. Rutkowski M., Grzegorczyk K.: [Colorimetric determination of vitamin C concentration in blood plasma with phosphotungstic reagent – a modification of Kyaw method]. Diagn. Lab., 34, 511, 1998 (in Polish).
  22. Savory L.A. et al.: Selenium supplementation and exercise: effect on oxidant stress in overweight adults. Obesity (Silver Spring), 20, 794, 2012.
  23. Soudani N., et al.: Cardioprotective effects of selenium on chromium (VI)-induced toxicity in female rats. Ecotoxicol. Environ. Saf., 74, 513, 2011.
  24. Tanguy S. et al.: Impact of dietary selenium intake on cardiac health: Experimental approaches and human studies. Mol. Nutr. Food Res., 56, 1106, 2012.
  25. Venardos K. et al.: Effects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia–reperfusion. J. Trace Elem. Med. Biol., 18, 81, 2004.
  26. Zhan X.A. et al.: Effects of different selenium source on selenium distribution, loin quality and antioxidants status in finishing pigs. Anim. Food Sci. Technol., 132, 202, 2007.
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