Current Issues of Pharmacy and Medical Sciences

The effect of selenium supplementation in organic and in organic form on oxidant balance in rat heart and femoral muscle

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 287-291


Chair and Department of Medical Chemistry, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.3/a.10


Total antioxidant status (TAS), activity of antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GPx), concentrations of non-enzymatic antioxidants - ascorbic acid (AA) and reduced glutathione (GSH) as well as concentration of lipid peroxidation marker - malonyldialdehyde (MDA) were determined in heart and femoral muscle of rats receiving different selecompounds (inorganic selenite and organic selenosemicarbazide of chain structure and selenazoline of ring structure). Chain selenosemicarbazide markedly decreased TAS values vs. control without Se-supplementation in heart. GPx was significantly depressed vs. control in heart of animals receiving organic selenium. Ring selenazoline decreased heart AA, whereas selenosemicarbazide increased heart GSH. Inorganic selenite diminished femoral muscle GSH. Selenium supplementation distinctly inhibited process of lipid peroxidation - MDA was decreased in Se-given animals, particularly in heart. As organic ring selenocompound depressed heart MDA to the highest degree, did not impair total antioxidant status and caused no disturbance of antioxidant barrier in femoral muscle, it could be suggested that further research may reveal possibilities of its application as a Se-supplement.

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selenium, rats, antioxidant barrier, lipid peroxidation


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