Current Issues of Pharmacy and Medical Sciences

Dentin adhesion and matrix metalloproteinases

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 282-286


Chair and Department of Conservative Dentistry and Endodontics, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.3/a.09


One of the challenges of contemporary conservative dentistry is prevention of secondary caries. Despite the growing bond strength  values, which is obtained by chemical and technical improvements, rapid solubility and low durability still make a problem. The main reason of failure in adhesion is degradation of the collagens fibrils – the component of hybrid layer. The ground of this action can be matrix metalloproteinases (MMPs) – host-derived enzymes, which play a role in many physiological but also pathological processes. Basing on literature the authors divide them into groups and describe their structure and substrates.

Files to download


metalloproteinases, bonding, adhesive resins, hybrid layer


  1. Abate P.F., Rodriguea V.I., Macchi R.L.: Evaporation of solvent in one-bottle adhesives. J. Dent., 28, 437, 2000.
  2. Breschi L. et al.: Dental adhesion review: aging and stability of the bonded interface. Dent. Mater., 24, 90, 2008.
  3. Breschi L. et al.: Electric impulse-assisted application of self-etch adhesives to dentin. J. dent. Res., 85, 1092, 2006.
  4. Buononcore M.G.: A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. J. Dent. Res., 34, 849, 1955.
  5. Cadenaro M. et al.: Degree of conversion and permeability of dental adhesives. Eur. J. Oral Sci., 113, 525, 2005.
  6. Carrilho M.R.O. et al.: Chlorhexidine preserves dentin bond in vitro. J. Dent. Res., 86, 90, 2007.
  7. Chaharom M.E.E. et al.: Effect of chlorhexidine on the shear bond strength of self-etch adhesives to dentin. Afr. J. Biotechnol., 49, 10054, 2011.
  8. Chaussain-Miller C. et al.: The role of matrix metalloproteinases (MMPs) in human caries. J. Dent. Res., 1, 22, 2006.
  9. De Munck J. et al.: A critical review of the durability of adhesion to tooth tissue: methods and results. J. Dent. Res., 84, 118, 2005.
  10. Gohlke U. et al.: The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP-2): structural implications for its function. FEBS Lett., 378, 126, 1996.
  11. Gończowski K. et al.: Szczelność brzeżna wypełnień z kompozytu Filtek Z250 (3M Espe) zakładanych z zastosowaniem różnych systemów łączących – badania laboratoryjne. Porad. Stomatol., 2, 12, 2004.
  12. Hashimoto M. et al.: Permeability of adhesive resin films. J. Biomed. Mater. Res. Part B, 74, 699, 2005.
  13. Hebling J. et al.: Chlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo. J. Dent. Res., 84, 741, 2005.
  14. Ikeda T. et al.: Effect of evaporation of primer components on ultimate tensile strengths of primer-adhesive mixture. Dent. Mater., 21, 1051, 2005.
  15. Jodkowska E., Wagner L.: Materiały łączące z zębiną. Część I. e-Dentico, 2, 26, 2005.
  16. Lipka D., Boratyński J.: Metaloproteinazy MMP. Struktura i funkcja. Postępy Hig. Med. Dośw. (online), 62, 328, 2008.
  17. Mjör I.A., Gordan V.V.: Failure, repair, refurbishing and longevity of restorations. Oper. Dent., 27, 528, 2002.
  18. Nagase H.: Activation mechanisms of matrix metalloproteinases. Biol. Chem. 378, 151, 1997.
  19. Pashley E.L. et al.: Effects of HEMA on water evaporation from water-HEMA mixtures. Dent. Mater., 14, 6, 1998.
  20. Pasquantonio G. et al.: Electric device improves bonds of simplified etch-and-rinse adhesives. Dent. Mater., 23, 513, 2007.
  21. Reis A. et al.: Effect of prolonged application times on the durability of resin-dentin bonds. Dent. Mater., 5, 639, 2008.
  22. Sekhon B. S.: Matrix metalloproteinases – an overview. Res. Rep. Biol., 1, 1, 2010.
  23. Sternlicht M.D., Werb Z.: How matrix metalloproteinases regulate cell behaviour. Annu. Rev. Cell Dev. Biol., 17, 463, 2001.
  24. Sulkala M.: Matrix metalloproteinases (MMPs) in the dentin-pulp complex of healthy and carious teeth. Oulu University Press, Oulu  2004.
  25. Szewczenko J., Obersztyn I., Krawczyk A.: Sposoby adhezji systemów wiążących do zębiny – przegląd materiałów na podstawie piśmiennictwa. Porad. Stomatol., 6, 176, 2008.
  26. Szpak A.: Przegląd systemów adhezyjnych na podstawie piśmiennictwa. Część I. Mag. Stom., 207, 47, 2009.
  27. Tay F.R., Pashley D.H.: Dental adhesives of the future. J. Adhes. Dent., 4, 91, 2002.
  28. Van Dijken I.W.: Clinical evaluation of three adhesive systems in class V non-carious lesions. Dent. Mater., 16, 285, 2000.
  29. Van Landuyt K.L. et al.: Monomer-solvent phase separation in one step self-etch adhesives. J. Dent. Res., 84, 183, 2005.
  30. Van Meerbeek B. et al.: Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges. Oper. Dent., 28, 215, 2003.
  31. Vennat E., Aubry D., Degrange M.: Collagen fiber network infiltration: permeability and capillary infiltration. Transport Porous Med., 84, 717, 2010.
  32. Visse R., Nagasse H.: Matrix metalloproteinases and tissues inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92, 827, 2003.
  33. Wang Y., Spencer P.: Hybridization efficiency of the adhesive/dentin interface with wet bonding. J. Dent. Res., 82, 141, 2003.
prev next



June 2020

Mon Tue Wed Thu Fri Sat Sun
01 02 03 04 05 06 07
08 09 10 11 12 13 14
15 16 17 18 19 20 21
22 23 24 25 26 27 28
29 30