Current Issues of Pharmacy and Medical Sciences

Influence of combined treatment with mianserin and simvastatin on selected biochemical serum parameters of liver and kidney ...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 263-266

MARIOLA HERBET, MONIKA GAWROŃSKA-GRZYWACZ,
MAGDALENA IZDEBSKA, EWA JAGIEŁŁO-WÓJTOWICZ

Department of Toxicology, Medical University of Lublin, Poland


DOI: 10.12923/j.2084-980X/26.3/a.04

Abstract

The aim of the present study was to assess the impact of combined 14-day treatment with mianserin (10 mg/kg) and simvastatin (1 or 10 mg/kg) on selected biochemical liver and kidney parameters in rats (AST and ALT activities and the concentrations of AFP, total protein, urea, creatinine and ß2-M). The results showed the increase in both transaminases activities, creatinine concentration and the decrease of AFP, total protein and ß2-M concentrations. The results indicate that 14-day combined administration of mianserin with simvastatin negatively affects the liver functioning. The observed changes in kidney biochemical parameters may suggest a risk of renal dysfunction during long-term combined treatment with these drugs.
 

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Keywords

mianserin, simvastatin, biochemical liver and kidney parameters, rats

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