Current Issues of Pharmacy and Medical Sciences

Evaluation of physicochemical and mechanical properties of polymeric formulations for use in the oral cavity

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 252-257

KAROLINA MARIA NOWAK, KAZIMIERA HENRYKA BODEK

Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Poland


DOI: 10.12923/j.2084-980X/26.3/a.02

Abstract

The aim of this research was to create and investigate a formulation that could be placed within post-extraction alveolus. The main material used in this work is a natural polymer, known as microcrystalline chitosan (MCCh). It was formulated as an aqueous hydrogel with the addition of the cross-linking agent (CaCl2) and various plasticizers (propylene glycol, glycerol and sorbitol). The swelling of the preparations was tested by three different methods under completely different acceptor fluids such as distilled water, phosphate buffer and simulated saliva. The pH was measured on the surfaces of each formulation, as well as the pH of the acceptor fluids; evidently, both of them had a similar pH to that of the oral cavity. Additionally, mechanical properties of the tested materials such as hardness, springiness and cohesiveness were evaluated. Based on research, the best compositions of materials were chosen to obtain preparations of the desired geometry and mechanical characteristics. The results from the study are able to prove that MCCh not only creates a neutral environment within the oral cavity but also, due to its significant absorptive properties, can reduce exu date and po ten tially be considered as a new carrier for medicinal substances used in dental implantation and management.

 

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Keywords

polymeric formulations, phosphate buffer, simulated saliva, swelling, mechanical properties

References

  1. Amasya G. et al.: Bioadhesive and mechanical properties of triamcinolone acetonide buccal gels, Turk J. Pharm. Sci., 9, 1, 2012.
  2. Babu G.D. et al.: Design and evaluation of controlled release mucoadhesive buccal tablets of nifedipine, JPSI 1, 58, 2012.
  3. Battenberg P. et al.: Development and testing of bioadhesive, fluoride-containing slow-release tablets for oral use. J. Pharm. Pharmacol., 43, 457, 1991.
  4. He P., Davis S.S., Illum L.: In vitro evaluation of the mucoadhesive properties of chitosan microspheres, Int. J. Pharm., 166, 75, 1998.
  5. Jones D.S. et al.: Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases, Pharm. Res., 13, 1734, 1996.
  6. Jones D.S., Woolfson A.D., Djokic J.: Texture profile analysis of bioadhesive polymeric semisolids: mechanical characterization and investigation of interactions between formulation components, J. Appl. Polym. Sci., 61, 2229, 1996.
  7. Muzzarelli R.A.A.: Chitosan composites with inorganic morphogenetic proteins and stem cells for bone regeneration, Carbohydr. Polym., 83, 1433, 2011.
  8. Peh K.K., Wong C.F.: Polymeric films as vehicle for buccal delivery: swelling, mechanical and bioadhesive properties, J. Pharm. Pharm. Sci., 2, 53, 1999.
  9. Perioli L. et al.: Novel mucoadhesive buccal formulation containing metronidazole for treatment of periodontal disease, J. Control. Rel., 95, 521, 2004.
  10. Perioli L. et al.: Chitosan and a modified chitosan as a agents to improve performances of mucoadhesive vaginal gels, Colloids Surf. B Biointerfaces, 66, 141, 2008.
  11. Pighinelli L., Kucharska M., Wawro D.: Preparation of microcrystalline chitosan, Lambert Academic Press pp. 18-29, 2012.
  12. Polish Pharmacopoeia IX. vol. 1, pp. 607. Polish Pharmaceutical Society. Warsaw, 2011.
  13. Saarai A. et al.: On the characterisation of sodium alginate gelatine-based hydrogels for wound dressing, J. Appl. Polym. Sci., 126, E79, 2012.
  14. Smart J.D.: Drug delivery using buccal-adhesive systems, Adv. Drug Deliv. Rev., 11, 253, 1993.
  15. Struszczyk H., Kivekäs O.: Microcrystalline chitosan – some areas of application, Br. Polym. J., 23, 261, 1990. 
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