Current Issues of Pharmacy and Medical Sciences

Evaluation of physicochemical and mechanical properties of polymeric formulations for use in the oral cavity

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 252-257


Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Poland

DOI: 10.12923/j.2084-980X/26.3/a.02


The aim of this research was to create and investigate a formulation that could be placed within post-extraction alveolus. The main material used in this work is a natural polymer, known as microcrystalline chitosan (MCCh). It was formulated as an aqueous hydrogel with the addition of the cross-linking agent (CaCl2) and various plasticizers (propylene glycol, glycerol and sorbitol). The swelling of the preparations was tested by three different methods under completely different acceptor fluids such as distilled water, phosphate buffer and simulated saliva. The pH was measured on the surfaces of each formulation, as well as the pH of the acceptor fluids; evidently, both of them had a similar pH to that of the oral cavity. Additionally, mechanical properties of the tested materials such as hardness, springiness and cohesiveness were evaluated. Based on research, the best compositions of materials were chosen to obtain preparations of the desired geometry and mechanical characteristics. The results from the study are able to prove that MCCh not only creates a neutral environment within the oral cavity but also, due to its significant absorptive properties, can reduce exu date and po ten tially be considered as a new carrier for medicinal substances used in dental implantation and management.


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polymeric formulations, phosphate buffer, simulated saliva, swelling, mechanical properties


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