Methods of nanoliposomes preparation
Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 2, Pages 203-205
Department of Monitored Pharmacotherapy, Faculty of Pharmacy, Medical University of Bialystok, Poland
During the last decade, nanoliposomes have attracted great interest of many researchers. This was caused by unusual properties of these molecules, such us their nanosize, biocompatibility, and biodegradability. Due to these properties, they can be widely applied in many fields, especially as carriers of active substances in cosmetics, food technology, agriculture, and nanotherapy. The application of nanoliposomes as drug nanocarriers in medicine allows for more effective treatment of many diseases (e.g. cancers, atherosclerosis, ocular diseases) [1,6,7]. The advantage of these nanocarriers used in medicine is cell-specific targeting, which is indispensable to attain drug concentration, requisite for optimum therapeutic efficacy in the target site, with accompanying side effects limited to the minimum. Furthermore, the efficacy of treatment with these carriers comes from enhancing bioavailability, improving controlled release, and enabling precision targeting of the entrapped compounds, due to a larger increased surface area . The aim of this paper is to present the current knowledge on the conventional methods of preparation of nanoliposomes, including microfluidization, extrusion, sonification technique, with particular emphasis on the advantages and disadvantages of each of these methods.
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nanoliposomes, liposomes, nanotherapy, nanocariers
- Charalambos A. et al.: Nanoparticles: A Promising Therapeutic Approach in Atherosclerosis., Current Drug Delivery, 2010,7(4): 303-311.
- Colas J.C. et al.: Microscopical investigations of nisin-loaded nanoliposomes preparated by Mozafari method and their bacterial targeting. Micron, 2007,38: 841-847.
- Hope M.J. et al.: Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential., Biochim Biophys Acta., 1985,10, (812): 55-65.
- Jafari S.M., He Y., Bhandari B.: Nanoemulsion production by sonification and microfluidization - a comparison. Int. J. Food Prop., 2006, 9: 475-485.
- Jesorka A., Orwar O.: Liposomes: Technologies and analytical applications. Annu. Rev. Annal Chem., 2008,1: 801-832.
- Kaiser J.M. et al.: Nanoliposomal monicycline for ocular drug delivery. Nanomedicine: NBM., 2013,9: 130-140.
- Khosravi-Darani K., Mozafari M.R.: Nanoliposome Potentials in Nanotherapy: A Concise Overview. Int. J. Nanosci.Nanotechnol., 2010,6: 3-13.
- Khosrani-Darani K. et al. The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy. Micron., 2007,38: 804-818.
- Mozafari M.R.: Liposomes: an overview of manufacturing techniques., Cel. Mol. Bio. Let., 2005,10: 711-719.
- Mozafari M.R.: Nanoliposomes: preparation and analysis. Methods Mol. Biol., 2010, 605: 29-50.
- Mozafari M.R. et al.: Role of nanocarrier systems in cancer nanotherapy. J. Liposome Res., 2009,19: 310-321.
- Mozafari M.R. et al.: Cytotoxicity evaluation of anionic nanoliposomes and nanolipopolexes prepared by the heating method without employing volatile solvents and detergents. Pharmazie., 2007, 62: 205-209.
- Mozafari M.R. et al.: Nanoliposomes and Their Applications in Food Nanotechnology. J. Liposome Res., 2008,18: 309-327.
- Park K.: Nanotechnology: What it can do for drug delivery., J. Control. Release.,2007, 120: 1-3.
- Sahoo S.K, Dilnawaz F., Krishnakumar S.: Nanotechnology in ocular drug delivery., Drug Discov. Today, 2008,13: 144-151.
- Mui B., Chow L., Hope M.J.: Extrusion technique to generate liposomes of defined size., Methods Enzymol., 2003, 367: 3-14.