Current Issues of Pharmacy and Medical Sciences

Comparison of fluconazole release from hydrogels with Syntalen MP and Syntalen KP and from hydrophilic cream

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 2, Pages 189-192


1Chair and Department of Applied Pharmacy
2Chair and Department of Medicinal Chemistry, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.2/a.15



Fluconazole is popular antifungal medicine, usually used per os in Candida spp. infections of the skin and mucous membranes, pityriasis versicolor, candidiasis organs, and also in the prophylaxis of fungal infections in patients with cancer and AIDS. There are attempts of formulation of the different forms of drug because of many side effects of fluconazole in oral administration. These are eye drops, injections and semisolid skin preparations. Thus, the aim of the study was preparing two hydrogels with Syntalen MP and Syntalen KP and hydrophilic cream, containing 1% of fluconazole and comparing the release of the substance from obtained preparations. At the beginning, gels and hydrophilic cream have been subjected to physical tests such as: slip and spreadability. Further, their rheological properties were evaluated. In the slip and spreadability tests, the cream had the best parameters, the rheological tests showed pseudoplastic character of flowing of gels and plastic flowing of the cream. All these three preparations showed the thixotropy. The release studies, conducted using the extracting chamber (according to FP IX) in Paddle Apparatus showed that the amount of released substance from gels is about two times bigger than from the cream, but the releasing from the gel with Syntalen MP is slightly better than from the gel with Syntalen KP.

Files to download


fluconazole release, hydrogels, hydrophilic cream, rheology


  1. Abdel-Mottaleb M.M.A. et al.: Preparation and evaluation of fluconazole gels. Egypt. J. Biomed. Sci., 23, 2007.
  2. Achim M. et al.: Topical dosage forms containing fluidextract of ruscus aculeatus: Formulation, preparation and physical characterization. Clujul Medical, 83, 99-103, 2010.
  3. Ayub A.C. et al.: Topical delivery of fluconazole: In vitro skin penetration and permeation using emulsions as dosage forms. Drug Dev.Ind. Pharm., 33, 273-280, 2010.
  4. Basha B.N., Prakasam K., Goli D.: Formulation and evaluation of gel containing fluconazole – antifungial agent. Int. J. Drug Res., 3, 109-128, 2011.
  5. Bonacucina G., Martelli S., Palmieri G.F.: Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents. Int. J. Pharm., 282, 115-130, 2004.
  6. Bonferoni M.C., et al.: A modifies Franz diffusion cell for simultaneous assessment drug release and washability of mucoadhesive gels. Pharm. Dev. Technol., 4, 45-53,1999.
  7. Bottari F.: Influence of drug concentration on in vitro release of salicylic acid from ointment bases. J. Pharm. Sci., 63, 1979-1983, 1974.
  8. Charlier C. et al: Fluconazole for the management of invasive candidiasis: where do we after 15 years?  J. Antimicrob. Chemother., 57, 384 -410, 2006.
  9. Fiebieg A., Janicki St., Sznitowska M.: Farmacja stosowana. PZWL Warszawa 2004.
  10. Gaikwad V. et al.: Effect of Carbopol 934 and 949 on fluconazole release from topical gel formulation: A factorial approach. Curr. Pharm. Res., 2, 487-493, 2012.
  11. Islam M.T. et al: Rheological characterization of topical Carbomer gels neutralized to different pH. Pharm. Res., 7, 1192-1199, 2004.
  12. Jimenez - Soriano M.M., Fresno- Contreras M.J., Selles F.: Development of a cream from a self-emulsifying base and moisturizing actives.  II Farmaco, 56, 513-522, 2001.
  13. Martin M.V.: The use of fluconazole and itraconazole in the treatment of Candida albicans infections: a review. J. Antimicrob. Chemother., 44, 429-437, 1999.
  14. Mathy F.X. et al: Fluconazole distribution in rat dermis following intravenous and topical application: A microdialysis study. J. Pharm. Sci., 4, 770-780, 2005.
  15. Mitkari B.V. et al: Formulation and evaluation of topical liposomal gel for fluconazole. Indian J. Pharm. Educ. Res., 4, 324-333, 2010.
  16. Nagoroje S. et al: Formulation and evaluation of ophthalmic delivery of fluconazole from ion activated in situ gelling system. Der Pharmacie Lettre, 4, 1228-1235, 2012.
  17. Pluta J. Koralewicz B.: Hydrożele, właściwości I zastosowanie w technologii postaci leku. I. Charakterystyka hydrożeli. Polym.Med., 34, 3-13, 2004.
  18. Polska Farmakopea IX, Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych. Warszawa, 2011.
  19. Sadasivudu P., Shastri N., Sadanandam M.: Development and validation of RP-HPLC and UV methods of analysis for fluconazole in pharmaceutical solid dosage forms. Int. J. Chem. Tech. Res., 1(4), 1131-1136, 2009.
prev next



July 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31