Current Issues of Pharmacy and Medical Sciences

Release kinetics of sulfadimidine sodium and trimethoprim from tablets containing different excipients prepared by wet granulati

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 2, Pages 183-188

Łukasz Zimmer, Piotr Belniak, Michał Szumiło, Regina Kasperek, Ewa Poleszak

Department of Applied Pharmacy, Medical University of Lublin, Poland


DOI: 10.12923/j.2084-980X/26.2/a.14

 

Abstract

In this study seven tablet batches were prepared by wet granulation process using different excipients such as: superdisintegrant – croscarmellose sodium (Ac- Di- Sol), silicon dioxide (Aerosil), lactose, pregelatinized starch (CPharm Gel) and microcrystalline cellulose (Avicel pH- 101). Sulfadimidine sodium (SDD-Na) and trimethoprim (TMP) were used as model active substances. Tablets were evaluated for uniformity of weight, hardness, friability, drug content, disintegration time and dissolution properties. To study the release kinetics of the drugs, data obtained from in vitro drug release studies were plotted into the following kinetic models: zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas. The obtained results demonstrate that SDD-Na release kinetics was best described by Higuchi model followed by first order model. TMP release kinetics was best explained by first order model followed by Higuchi model. The Hixson-Crowell plot showed good linearity for SDD-Na and TMP. Release exponents values for Korsmeyer-Peppas model were characteristic for anomalous transport (non-Fickian) which appears to indicate a coupling of the diffusion and erosion mechanism or super case II transport refers mainly to the erosion of the polymeric chain.

Files to download

Keywords

dissolution kinetics, kinetic models, tablet excipients, sulfadimidine sodium, trimethoprim, wet granulation

References

  1. Balasubramaniam J., Bee T.: Influence of superdisintegrants of the rate of drug dissolution from oral solid dosage forms.  Pharm. Tech., Apr. 1, 2009.
  2. Bourne D.W., Banker G.S., Rhodes C.T.: Marcel Dekker Inc, Modern pharmaceutics 4th Ed. New York NY, 67-92, 2002.
  3. Costa P., Sousa Lobo J. M.:  Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci., 13 (2), 123-133, 2001.
  4. Dash S., Narashima M.P., Lilakanta  N., Prasanta, C.: Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol. Pharm.,  67, 217-223, 2010.
  5. García C. V.,  Paim C. S.,  Steppe M., Schapoval E. E. S.: Development and validation of a dissolution test for rabeprazole sodium in coated tablets. J. Pharm. Biomed. Anal., 41 (3), 833-837, 2006.
  6. Hadjiioannou  T.P., Christian, G.D., Koupparis, M.A.: Quantitative calculations in pharmaceutical practice and research. VCH Publishers Inc., New York NY,  345-348, 1993.
  7. Higuchi, T.: Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci., 52, 1145-1149, 1963.
  8. Kanfer I.: Workshop Report-Challenges in Dissolution Testing: Equivalence and Surrogates. Dissolution Technol., 17 (3), 41-50, 2010
  9. Khamanga S.M., Walker R.B.: In Vitro Dissolution kinetics of captopril from microspheres manufactured by solvent evaporation. Dissolution. Technol., 19, 1, 2012.
  10. Kim  H., Fassihi R.: A new ternary polymeric matrix system for controlled drug delivery of highly soluble drugs. Diltiazem hydrochloride. Pharm. Res., 14 (10), 1415-1421, 1997
  11. Korsmeyer  R.W., Gurny  R., Doelker  E., Buri  P., Peppas  N.A.: Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm., 15, 25-35, 1983.
  12. Late S.G., Tu Y., Banga A.K.: Effects of disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets. Int. J. Pharm., 365, 4-11, 2009
  13. Ousama R., Dévay A.,  Saeed A.:  Dissolution Testing of Sublingual Tablets: A Novel In Vitro Method.  AAPS Pharm. Sci. Tech.,  12, 2,  2011.
  14. Siepmann J., Peppas N.A.:  Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Deliv. Rev., 48, 139-157, 2001.
  15. Underwood  T., Cadwalladaer D.: Automated potentiometric procedure for studying dissolution kinetics of acidic drugs under sink conditions. J.Pharm.Sci., 67 (8), 1163-1167, 1978.
  16. Zimmer Ł., Czarnecki W.: Derivative specrtrophotometric method for simultaneous determination of sulfadimidine and trimethoprim. Ann. UMCS Sect. DDD , 23, 1,  27-36, 2010.
  17. Zimmer Ł., Świąder K., Belniak P., Szumiło M., Zuń M., Kasperek R., Poleszak E.: Formulation and evaluation of sulfadimidine and trimethoprim tablets using wet granulation technique.  Curr. Issues Pharm. Med. Sci., 26, 202-206, 2012.

 

prev next

 

Calendar

July 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31