Current Issues of Pharmacy and Medical Sciences

The influence of coating on release of paracetamol from the multi-compartment systems

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 2, Pages 160-162

TOMASZ STAWARSKI1, EDMUND SIERADZKI1, BEATA BARAN1, AGNIESZKA STAWARSKA2

1Department of Applied Pharmacy and Bioengineering, Faculty of Pharmacy, Medical University of Warsaw
2Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw

DOI: 10.12923/j.2084-980X/26.2/a.09

 

Abstract

A multi-compartment system enables modification of medicinal substance release. Nine series of multi-compartment systems were prepared, where each contained 5 minitablets. Application of different envelopes (OPADRY II WHITE and ACRYL EZE – PINK), coating the individual minitablets and complete multi-compartment systems, allowed for modeling medicinal substance release from the tested drug forms. Dissolution test of paracetamol was tested. The results were processed using the Statistica 9.0 (StatSoft, USA).

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Keywords

multi-compartment system, modified release, minitablets, coated tablets, paracetamol

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