Ànalgesic and anti-inflammatory activities of traditional mongolian drug Garidi-5
Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 114-117
UUGANBAYAR BAATARTSOGT1,2, ARIUNAA ZUNDUI1, OLDOKH SUNDUI2, OTGONBAATAR URJIN2 ,
CHIMEDRAGCHAA CHIMEDTSEREN1, MUNKHZUL GANBOLD1
1Traditional Medical Science, Technology and Production Corporation of Mongolia
2Health Sciences University of Mongolia
Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its anti-inflammatory activity.
Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.
Results. The Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group. In assay data, the TNF-α secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 significantly reduced serum secretion of inflammatory mediators as compared to vehicle group.
Conclusion. In conclusion, these results suggested that Mongolian traditional drug Garidi-5 analgesic and anti-inflammatory effects.
Files to download
garidi-5, anti-inflammatory, carrageenan
- Aqil, F., Ahmad, I., and Owais, M. Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts. Biotechnol J 2006;1(10):1093-1102.
- Chit, K., Myint, W., Thein, K., Maw, W. W., Myint M.M., Than, A., and Khin, M. Cyclic AMP phosphodiesterase inhibitory activity and chemical screening of four medicinal plants. Pharmaceutical Biology 2001;39(3):181-183.
- Cullen, J. J., Conklin, J. L., Ephgrave, K. S. and Oberley, L. W. 1999. The role of antioxidant enzymes in the control of opossum gallbladder motility. J. Surg. Res. 86: 155-161.
- Dagvatseren B., Khishigjargal S., Narantsetseg G., at all. (2003) A reference book of traditional drug and medicinal materials. Ulaanbaatar, Mongolia. Traditional Medical Science, Technology and Production Corporation. 209-210.
- Franzotti, E.M. Santos C. V. F.,. Rodrigues H.M. S. L, Mour˜ao, M. R. Andrade R.H. V, and. Antoniolli A. R, “Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca),” Journal of Ethnopharmacology, vol. 72, no.1-2, pp. 273–278, 2000.
- Gacche, R. N. and Dhole, N. A. Antioxidant and Possible Anti-Inflammatory Potential of Selected Medicinal Plants Prescribed in the Indian Traditional System of Medicine. Pharmaceutical Biology 2006;44(5):389-395.
- Hiroshi Hikino' & Mitsuo Murayama. Mechanism of the antinociceptive action of mesaconitine: participation of brain stem and lumbar enlargement. Br. J. Pharmac. (1985), 85, 575-580
- Kundu AP, Mahato SB. Triterpenoids and their glycosides from Terminalia chebula. Phytochemistry1993;32(4):999-1002.
- Lu, T. C., Ko, Y. Z., Huang, Y .C., Lin, Y. C. and Peng, W. H. 2007. Analgesic and antiinflamematory activities of aqueous extract from Glycine tomentella root in mice. J. Ethnopharmacol. 113: 142-148.
- Mei Chou Lai, I-Min Liu, Shorong-Shii and Yuan-Hiun Chang. Radix Aconiti kusnezoffii Exhibits an Antinociceptive Activity Involvement at Central and Peripheral Nervous System. Journal of Food and Drug Analysis, Vol. 20, No. 2, 2012, Pages 501-509
- Parab, R. S. and Mengi, S. A. Hypolipidemic activity of Acorus calamus L. in rats. Fitoterapia 2002;73(6):451-455.
- Prakash Chandra Gupta. Biological and pharmacological properties of Terminalia chebula retz. (haritaki)- an overview. Int J Pharm Pharm Sci, vol 4, suppl 3, 62-68
- Pulliah T. Encyclopedia of world medicinal plants. New Delhi, India: Regency Pub Vol 4, pp1931-1934
- Saad B., Abouatta B. S., Basha W. et al., “Hypericum triquetrifolium derived factors downregulate the production levels of LPS-induced nitric oxide and tumor necrosis factor- in THP-1 cells,” Evidence-Based Complementary and Alternative Medicine, vol. 4, pp. 425–430, 2007.
- Shin TY , Jeong HJ , Kim DK , Kim SH , Lee JK , Kim DK ,Chae BS , Kim JH , Kang HW , Lee CM , Lee KC , Park ST , Lee EJ , Lim JP , Kim HM , Leen YM. Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis. J Ethnopharmacol 2001;74:133- 40.
- Srivastava A, Chandra A, Singh M, Jamal F, Rastogi P, Rajendran SM, Bansode FW, Lakshmi V. Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant. Reproductive Toxicol 2010;29:214–24.
- Vane, J. R. and Botting R. M. 1995. New insights into the mode of action of anti-inflammatory drugs. Inflamm. Res. 44: 1-10.
- Vinegar, R., Schreiber, W. and Hugo, R. 1969. Biphasic development of carrageenin odema in rats. J. Pharmacol. Exp. Ther. 166: 96-103.
- Yamada, K., Suzuki, E., Nakaki, T., Watanabe, S. and Kanba, S. 2005. Aconiti tuber increases plasma nitrite and nitrate levels in humans. J. Ethnopharmacol. 96: 165-169.