Current Issues of Pharmacy and Medical Sciences

Diagnosis of experimental stetohepatosis using ultrasound shear wave elastography

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 109-113

PETRO BODNAR1, OLEG DYNNYK3, GALYNA MYHALCHYSHYN1, TETIANA BEREGOVA2,
NAZARIY KOBYLIAK1, IRYNA PRYBYTKO2, MARIANA KONDRO4

1 National Bohomolets University, Kiev, Ukraine
2 UNN «Biology lnstitute» of Kiev National Shevchenko University, Ukraine
3 Medical theoretical and practical association «Medstroj», Ukraine
4 Lviv National Medical University of Danylo Galytsky, Ukraine

DOI: 10.12923/j.2084-980X/26.1/a.24

 

Abstract

According to available literature data, NAFLD may play crucial role in the pathogenesis of type 2 diabetes and other conditions connected with insulin resistance. In order to study the essence of the NAFLD, we have created an experimental model of the steatohepatosis. The mixed diet for 8 weeks consisting of standard food (47%), sweetened condensed milk (44%), vegetable oil (8%) and vegetable starch (1%) develops non-alcoholic steatohepatosis in the animals undergoing the experiment. The morphological signs of the non-alcoholic steatohepatosis comprised as follows in the hepatocytes of the rats undergoing the experiment: presence of fine-drop fattiness (fine-drop steatosis) and accumulation of fat vacuoles shifting the nucleus towards the cell peripheral. Substantial increase in the liver pulp of the animals undergoing the experiment defined using the ultrasound shear wave elastography technique is indicative of the presence of the non-alcoholic steatohepatosis. The ultrasound shear wave elastography technique can be used as a non-invasive diagnosis marker of the non-alcoholic steatohepatosis. The said diagnosis technique has been recommended for the first time.

Keywords

steatohepatosis, non-alcoholic fatty liver disease, ultrasound liver elastography

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