Current Issues of Pharmacy and Medical Sciences

Postprandial hyperglycemia changed fucosylated pattern of the oesophageal epithelial barrier activity through the nitrogen oxide

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 94-98

OKSANA ZAYACHKIVSKA1, NAZAR HRYCEVYCH1, ANTONINA YASCHENKO2

1 Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
2 Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

DOI: 10.12923/j.2084-980X/26.1/a.20

 

Abstract

The present study was designed to evaluate the role of postprandial hyperglycemia (PHG) on oesophageal epithelial barrier (OEB) integrity via evaluation expression of fucosylated glycans by PFA and LABA labeling and mechanism in formation PHG induced pre-ulcer lesions through the NO/NOS activity in OEB and therapeutic potential and mechamism of L-Tryptophan influence on OEB lesions. Fucosaylated glycans are contributed in OEB integrity. NO/NOS activity seem to play a critical role in OEB ulcerogenesis because blocking its activity aggravates experimental OEB lesions, most likely through the inflammation, vascular and perivascular changes.

Keywords

oesophagus, postprandial hyperglycemia, NO, histochemistry, fucosylated glycans

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