Blood serum amino acids profile in patients with Multiple Sclerosis
Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 50-53
BEATA JAKUBOWSKA-SOLARSKA, MAGDALENA NIEŚPIAŁOWSKA
Department of Laboratory Diagnostics, Medical University of Lublin, Poland
Multiple sclerosis is the most common demyelinating disease of the central nervous system, affecting mostly young people. There were many risk factors for MS identified, however a direct cause of the disease is still unknown. Pathological changes in the SM lead to the myelin sheath damage around axons, what prevents proper transmission of nerve impulses in the central nervous system. The aim of this study was analyzing and comparing the amino acids profile in the blood serum of MS patients to control group of healthy individuals and evaluating the relationship between them. Significant (p<0.05) differences in the level of glutamate, aspartate and taurine in the blood serum of MS patients were revealed. A positive glutamate and aspartate level correlation in the serum has been demonstrated. Gender is significant only in the case of glutamate level in blood serum. The studies highlight the important role of neurotransmitters in MS and are the initial step in proteomic research.
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Multiple sclerosis (MS), amino acid, aspartic acid, glutamic acid, taurine
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