Current Issues of Pharmacy and Medical Sciences

Effect of nonionic surfactants on the release of paracetamol from suppositories

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 1, Pages 40-44


Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland

DOI: 10.12923/j.2084-980X/26.1/a.08



The preparation suppositories contain 250 mg of paracetamol on different bases using Novata BD, Novata BCF and composition of Novata BCF/BD (1:1). Suppositories were prepared by the fusion method. The prepared formulations with or without surfactants (Tween 80, Span 60) at concentrations of 2% and 4% (w/w) were tested for hardness, to tal time of de for ma tion, disintegration time,
content uniformity and release of the drug. The release of the drug was carried in the apparatus with the stirrer shade in phosphate buffer (pH 7.2) at 100 rpm. The physical properties of the prepared suppositories were according with the requirement of Polish Pharmacopoeia 9th edition. Addition of 4 % Tween 80 to suppository bases significantly increased the drug release from all the investigated formulations. However, incorporation of Span 60 did not result in improvement of the drug release significantly.


suppository bases, surfactants, paracetamol


  1. Chicco D et al.: Correlation of in vitro and in vivo paracetamol availability from layered excipient suppositories. Int. J. Pharm., 189, 147, 1999.
  2. Czarnecki W, Kasperek R.: Nowy uniwersalny aparat do uwalniania substancji leczniczych z dozowanych postaci leku. Patent R.P.Nr P 337979 z 21.01.2000r., Biomed Wytwórnia Surowic i Szczepionek w Lublinie.
  3. El-Faham et al.: Formulation, release characteristic and evaluation of ibuprofen suppositories. Int. J. Pharm, 61, 1, 1990.
  4. Hanaee I et all.: The role of various surfactants on the release of salbutamol from suppositories. Il Farmaco., 59, 903, 2004.
  5. Hosny, E. A., Abdel-Hady, S. S., Eltahir, K. E. H.: Formulation, in-vitro release and ex-vivo spasmolytic effects of mebeverine hydrochloride suppositories containing polycarbophil or polysorbate 80. International Journal of Pharmaceutics, 142, 163–168, 1996.
  6. Orlova T. V, Pancrusheva T.A.: Melting point and softening time of suppositories containing nonsteroidal anti-inflammatory drugs. Pharmaceutical chemistry Journal, 44 (7), 54, 2010.
  7. Orlova T. V et al.: Biofarmaceutical study of suppositories containing nonsteroidal anti-inflammatory drugs. Pharmaceutical chemistry Journal, 44 (5), 265, 2010.
  8. Pagay S et al.: Influence of vehicule dielectric properties on acetaminophen bioavailability from polyethylene glycol suppositories. J. Pharm. Sci.63 (1), 44, 1974.
  9. Polish Pharmacopoeia IX, PZWL, Warsaw, 2011.
  10. Realdon N et al.: Effects of surfactant characteristics on drug availability from suppositories. Pharmazie, 63(6), 459, 2008.
  11. Shegokar R., Singh K. K.: Comparative evaluation of pediatric paracetamol suppository in rabbits. First International Indo-Japanese Conference, Mumbai, India 25–29 November 2005.
  12. Shegokar R, Singh K.: In-vitro release of paracetamol from Suppoire suppositories: Role of additives. Malaysian J. Pharm. Sci. 8 (1), 57, 2010.
  13. Takatori T., Shimono N., Higaki K., Kimura T.: Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting points. International Journal of Pharmaceutics, 2006, 278, 275–282.
  14. Tsagareishvili G et al.: Biopharmaceutical, Pharmaceutical, and Technical Aspects of Creating Soft Medicinal Forms: Rectal Drugs, Metsniereba. Tbilisi 1987.
  15. Varshney H. M, Tanwar Y. S.: Effect of different surfactants on the release pattern of cocoa butter suppositories containing flurbiprofen sodium. Acta Pharmaceutica Sciencia, 52, 129, 2010.
prev next



July 2020

Mon Tue Wed Thu Fri Sat Sun
    01 02 03 04 05
06 07 08 09 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 31